作为抗结核分枝杆菌免疫受体的Toll样受体4：一项系统综述
Toll-Like Receptor 4 as an Immune Receptor Against Mycobacterium tuberculosis: A Systematic Review.
作者信息
Sepehri Zahra, Kiani Zohre, Kohan Farhad, Ghavami Saeid
机构信息
Department of Internal Medicine, Zabol University of Medical Sciences, Zabol, Iran.
Zabol Medicinal Plant Research Center, Zabol University of Medical Sciences, Zabol, Iran and Kerman University of Medical Sciences, Kerman, Iran.
出版信息
Lab Med. 2019 Apr 8;50(2):117-129. doi: 10.1093/labmed/lmy047.
OBJECTIVE
To review the main Mycobacterium tuberculosis (Mtb) pathogen-associated molecular patterns (PAMPs) and the roles played by toll-like receptor (TLR)4 in determination of Mtb infection outcome.
METHODS
Several scientific databases, including Scopus, PubMed, and Google Scholar, were used for searching appropriate research articles from the literature for information on our topic.
RESULTS
TLR4 plays positive roles in induction of immune responses against Mtb and participates in eradication of the infection. Some limited investigations approved the roles of TLR4 in induction of apoptosis in macrophages during tuberculosis (TB) and attenuation of immune responses in some situations.
CONCLUSIONS
TB outcome appears to be dependent on TLR4/Mtb interaction and several factors, including bacterial load and immune or nonimmune cells, as hosts. Also, other TLR/Mtb interactions can affect TLR4 responses.
目的
综述结核分枝杆菌（Mtb）主要的病原体相关分子模式（PAMPs）以及Toll样受体（TLR）4在决定Mtb感染结局中所起的作用。
方法
使用包括Scopus、PubMed和谷歌学术在内的多个科学数据库，从文献中搜索有关我们主题的合适研究文章以获取信息。
结果
TLR4在诱导针对Mtb的免疫反应中发挥积极作用，并参与感染的清除。一些有限的研究证实了TLR4在结核病（TB）期间诱导巨噬细胞凋亡以及在某些情况下减弱免疫反应中的作用。
结论
TB结局似乎取决于TLR4/Mtb相互作用以及几个因素，包括细菌载量和作为宿主的免疫或非免疫细胞。此外，其他TLR/Mtb相互作用可影响TLR4反应。
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