Yamamoto Tatsuya, Uchiyama Tomoyuki, Higuchi Yoshinori, Asahina Masato, Hirano Shigeki, Yamanaka Yoshitaka, Weibing Liu, Kuwabara Satoshi
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Neurology, Dokkyo Medical College, Tochigi, Japan.
J Neurol Sci. 2017 Aug 15;379:18-21. doi: 10.1016/j.jns.2017.05.037. Epub 2017 May 19.
We aimed to examine temporal changes in health-related quality of life (HRQOL) and its relationship with motor and cognitive functions in patients with Parkinson's disease (PD) after subthalamic nucleus deep brain stimulation (STN-DBS).
In total, 31 patients with PD were enrolled in this study (mean age: 66.7±0.9years; mean disease duration: 11.6±3.7years). Participants completed the Unified Parkinson's Disease Rating Scale and the Parkinson's Disease Questionnaire-39. Cognitive function was assessed using the Mini Mental State Examination, the Frontal Assessment Battery, and the Montreal Cognitive Assessment. Postoperative evaluation was performed at three months, one year, three years, and five years after surgery; temporal changes in the correlation between HRQOL and motor and cognitive functions were evaluated at all follow-up periods.
All patients completed postoperative clinical evaluations after three months, after one year. Of the 31 participants, twelve completed postoperative clinical evaluations after three years and seven after five years. Motor functions showed significant improvement over the five-year follow-up period. The mobility subdomain of the HRQOL worsened whereas the total score did not change significantly over years. Cognitive functions were not significantly impaired during follow-up periods. HRQOL was basically not significantly correlated with motor and cognitive functions during the follow-up period.
The mobility subdomain of the HRQOL worsened after surgery, and the improvement in motor functions was basically not correlated with HRQOL after STN-DBS in patients with PD. Cognitive functions were not significantly impaired during follow-up periods.
我们旨在研究丘脑底核深部脑刺激（STN-DBS）术后帕金森病（PD）患者健康相关生活质量（HRQOL）的时间变化及其与运动和认知功能的关系。
本研究共纳入31例PD患者（平均年龄：66.7±0.9岁；平均病程：11.6±3.7年）。参与者完成了统一帕金森病评定量表和帕金森病问卷-39。使用简易精神状态检查表、额叶评估量表和蒙特利尔认知评估量表评估认知功能。术后评估在术后3个月、1年、3年和5年进行；在所有随访期评估HRQOL与运动和认知功能之间相关性的时间变化。
所有患者在术后3个月、1年后完成了术后临床评估。31名参与者中，12名在术后3年完成了术后临床评估，7名在术后5年完成了评估。在5年的随访期内运动功能有显著改善。HRQOL的活动亚领域恶化，而总分多年来没有显著变化。随访期间认知功能没有显著受损。随访期间HRQOL与运动和认知功能基本无显著相关性。
PD患者STN-DBS术后HRQOL的活动亚领域恶化，运动功能的改善与术后HRQOL基本无关。随访期间认知功能没有显著受损。
