Ma Xiaoye, Meng Guilin, Tan Yan, Liu Xiaohui, Zhao Yichen, Yu Jia, Jin Aiping, Zhao Yanxin, Liu Xueyuan
Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Front Neurol. 2018 Sep 11;9:754. doi: 10.3389/fneur.2018.00754. eCollection 2018.
Personality impacts life expectancy and comprehensive treatment efficacy for patients with Parkinson's disease (PD). However, current research fails to involve the family caregiver's personality despite significant external support provided by family caregivers. This study explored neuroticism and conscientiousness personality factors of the patient and family caregiver associated with quality of life (QoL) of PD patients. 134 couples of patients presenting with PD and their family caregivers that met inclusion criteria, were recruited for this cross-sectional study at Shanghai Tenth People's Hospital from October 2015 to 2017. The Parkinson's Disease Questionnaire-39 Items (PDQ-39) for QoL, including the physical component summary (PCS) and mental component summary (MCS), the Neuroticism Extraversion Openness Five-Factor Inventory (NEO-FFI) for neuroticism and conscientiousness personalities, and the Unified Parkinson's Disease Rating Scale (UPDRS) for PD severity questionnaires were employed. Multivariate stepwise linear regression determined the contributions of demographic, clinical and personality variables in PDQ-39, PCS, and MCS. PD patients and neuroticism were significantly associated with total PDQ-39, PCS, and MCS. Additionally, conscientiousness was significantly associated with PDQ-39 and PCS. After adding neuroticism and caregiver conscientiousness personality, the importance of neuroticism for the QoL model dramatically decreased, and caregiver conscientiousness personality was associated with lower scores in total PDQ-39 and PCS. We revealed a significant association between neuroticism and physical or mental status of PD patients; however, this association decreased when caregiver conscientiousness was added to the model. Moreover, conscientiousness of patients and caregivers were associated with improved QoL.
人格会影响帕金森病（PD）患者的预期寿命和综合治疗效果。然而，尽管家庭照顾者提供了重要的外部支持，但目前的研究并未涉及家庭照顾者的人格。本研究探讨了与PD患者生活质量（QoL）相关的患者及家庭照顾者的神经质和尽责性人格因素。2015年10月至2017年，在上海第十人民医院招募了134对符合纳入标准的PD患者及其家庭照顾者，进行这项横断面研究。采用帕金森病问卷39项（PDQ - 39）评估生活质量，包括身体成分总结（PCS）和心理成分总结（MCS）；采用神经质外向开放性五因素问卷（NEO - FFI）评估神经质和尽责性人格；采用统一帕金森病评定量表（UPDRS）评估PD严重程度问卷。多变量逐步线性回归确定了人口统计学、临床和人格变量对PDQ - 39、PCS和MCS的影响。PD患者和神经质与总的PDQ - 39、PCS和MCS显著相关。此外，尽责性与PDQ - 39和PCS显著相关。加入神经质和照顾者尽责性人格后，神经质对生活质量模型的重要性显著降低，照顾者尽责性人格与总的PDQ - 39和PCS得分较低相关。我们揭示了神经质与PD患者的身体或精神状态之间存在显著关联；然而，当将照顾者尽责性加入模型时，这种关联减弱。此外，患者和照顾者的尽责性与生活质量的改善相关。
