Dalgo Aguilar Paola, Loján González Cisne, Córdova Rodríguez Ana, Acurio Páez Katherine, Arévalo Ana Paulina, Bobokova Jana
Departamento de Ciencias de la Salud, Sección Genética Humana, Microbiología y Bioquímica Clínica, Universidad Técnica Particular de Loja, Loja, Ecuador.
Sociedad de Lucha Contra el Cáncer, Hospital SOLCA Núcleo de Loja, Loja, Ecuador.
Infect Dis Obstet Gynecol. 2017;2017:8572065. doi: 10.1155/2017/8572065. Epub 2017 Jun 22.
Human papillomavirus (HPV) is the primary infectious agent for the development of cervical cancer, although the presence of the virus alone is insufficient for viral development and proliferation; this can be attributed to the increase in potential oncogenic risk, along with other risk factors. In the present investigation, the prevalence of high-risk HPV was determined from samples of premalignant or malignant cervical cytology in women from the southern region of Ecuador. The kit we used was able to detect genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59. In addition, 64.5% of the analyzed samples were positive for HPV, with genotypes 16 and 18 being the most prevalent (16 was detected in 148 samples and 18 in 108). Genotypes 58 and 51 were the third most frequent simple and multiple infections, respectively. The data are very similar to those obtained worldwide, suggesting that the strategy of sex education, and the use of vaccines as primary prevention agents, could significantly decrease the incidence and mortality rate of cervical cancer in the southern region of Ecuador.
人乳头瘤病毒（HPV）是宫颈癌发生的主要感染源，尽管仅病毒的存在不足以导致病毒发展和增殖；这可归因于潜在致癌风险的增加以及其他风险因素。在本调查中，从厄瓜多尔南部地区女性的癌前或恶性宫颈细胞学样本中确定了高危HPV的流行情况。我们使用的试剂盒能够检测16、18、31、33、35、39、45、51、52、56、58和59型。此外，64.5%的分析样本HPV呈阳性，其中16型和18型最为常见（148个样本检测到16型，108个样本检测到18型）。58型和51型分别是第三常见的单一感染和多重感染类型。这些数据与全球范围内获得的数据非常相似，表明性教育策略以及使用疫苗作为主要预防手段可显著降低厄瓜多尔南部地区宫颈癌的发病率和死亡率。
