成体干细胞在风湿性疾病治疗中的潜在作用。
The potential role of adult stem cells in the management of the rheumatic diseases.
作者信息
Franceschetti Tiziana, De Bari Cosimo
机构信息
Arthritis & Regenerative Medicine Laboratory, Aberdeen Centre for Arthritis and Musculoskeletal Health, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
出版信息
Ther Adv Musculoskelet Dis. 2017 Jul;9(7):165-179. doi: 10.1177/1759720X17704639. Epub 2017 Apr 20.
Abstract
Adult stem cells are considered as appealing therapeutic candidates for inflammatory and degenerative musculoskeletal diseases. A large body of preclinical research has contributed to describing their immune-modulating properties and regenerative potential. Additionally, increasing evidence suggests that stem cell differentiation and function are disrupted in the pathogenesis of rheumatic diseases. Clinical studies have been limited, for the most part, to the application of adult stem cell-based treatments on small numbers of patients or as a 'salvage' therapy in life-threatening disease cases. Nevertheless, these preliminary studies indicate that adult stem cells are promising tools for the long-term treatment of rheumatic diseases. This review highlights recent knowledge acquired in the fields of hematopoietic and mesenchymal stem cell therapy for the management of systemic sclerosis (SSc), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and osteoarthritis (OA) and the potential mechanisms mediating their function.
摘要
成体干细胞被认为是治疗炎性和退行性肌肉骨骼疾病的有吸引力的候选者。大量临床前研究有助于描述它们的免疫调节特性和再生潜力。此外，越来越多的证据表明，在风湿性疾病的发病机制中，干细胞的分化和功能受到破坏。在很大程度上，临床研究仅限于对少数患者应用基于成体干细胞的治疗，或在危及生命的疾病病例中作为“挽救”疗法。然而，这些初步研究表明，成体干细胞是长期治疗风湿性疾病的有前景的工具。本综述重点介绍了在造血干细胞和间充质干细胞治疗系统性硬化症（SSc）、系统性红斑狼疮（SLE）、类风湿关节炎（RA）和骨关节炎（OA）领域获得的最新知识，以及介导其功能的潜在机制。
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