肯尼亚沿海地区裂谷热血清阳性率
Rift Valley Fever Seroprevalence in Coastal Kenya.
作者信息
Grossi-Soyster Elysse N, Banda Tamara, Teng Crystal Y, Muchiri Eric M, Mungai Peter L, Mutuku Francis M, Gildengorin Ginny, Kitron Uriel, King Charles H, Desiree Labeaud A
机构信息
Stanford University School of Medicine, Stanford, California.
Children's Hospital Oakland Research Institute, Oakland, California.
出版信息
Am J Trop Med Hyg. 2017 Jul;97(1):115-120. doi: 10.4269/ajtmh.17-0104.
Rift Valley fever virus (RVFV) causes severe disease in both animals and humans, resulting in significant economic and public health damages. The objective of this study was to measure RVFV seroprevalence in six coastal Kenyan villages between 2009 and 2011, and characterize individual-, household-, and community-level risk factors for prior RVFV exposure. Sera were tested for anti-RVFV IgG via enzyme-linked immunosorbent assay. Overall, 51 (1.8%; confidence interval [CI] 1.3-2.3) of 2,871 samples were seropositive for RVFV. Seroprevalence differed significantly among villages, and was highest in Jego Village (18/300; 6.0%; CI 3.6-9.3) and lowest in Magodzoni (0/248). Adults were more likely to be seropositive than children ( < 0.001). Seropositive subjects were less likely to own land or a motor vehicle ( < 0.01), suggesting exposure is associated with lower socioeconomic standing ( = 0.03). RVFV exposure appears to be low in coastal Kenya, although with some variability among villages.
裂谷热病毒（RVFV）可在动物和人类中引发严重疾病，造成重大经济损失和公共卫生损害。本研究的目的是测定2009年至2011年间肯尼亚沿海六个村庄的RVFV血清流行率，并确定个体、家庭和社区层面既往RVFV暴露的风险因素。通过酶联免疫吸附测定法检测血清中的抗RVFV IgG。总体而言，2871份样本中有51份（1.8%；置信区间[CI] 1.3 - 2.3）RVFV血清呈阳性。各村庄的血清流行率差异显著，在杰戈村最高（18/300；6.0%；CI 3.6 - 9.3），在马戈佐尼最低（0/248）。成年人血清呈阳性的可能性高于儿童（<0.001）。血清呈阳性的受试者拥有土地或机动车的可能性较小（<0.01），这表明暴露与较低的社会经济地位相关（=0.03）。肯尼亚沿海地区的RVFV暴露似乎较低，不过各村庄之间存在一定差异。
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