Muiruri Samuel, Kabiru Ephantus W, Muchiri Eric M, Hussein Hassan, Kagondu Frederick, LaBeaud A Desirée, King Charles H
Department of Pathology, Kenyatta University, Nairobi, Kenya; Vector-Borne Diseases Control Unit, Ministry of Health, Nairobi, Kenya; Office of Director of Health, Garissa County, Kenya; Department of Ophthalmology, Thika Level 5 Hospital, Ministry of Health, Thika, Kenya; Center for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California; Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio.
Department of Pathology, Kenyatta University, Nairobi, Kenya; Vector-Borne Diseases Control Unit, Ministry of Health, Nairobi, Kenya; Office of Director of Health, Garissa County, Kenya; Department of Ophthalmology, Thika Level 5 Hospital, Ministry of Health, Thika, Kenya; Center for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California; Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio
Am J Trop Med Hyg. 2015 Feb;92(2):394-400. doi: 10.4269/ajtmh.14-0440. Epub 2014 Dec 22.
Few studies have focused on Rift Valley fever virus (RVFV) transmission in less arid, transitional landscapes surrounding known high-risk regions. The objective of this study was to identify evidence of RVFV exposure in Bodhei Village in a forested area at the edge of the RVFV-epidemic Garissa region. In a household cluster-based survey conducted between epidemics in early 2006, 211 participants were enrolled. Overall seroprevalence for anti-RVFV was high (18%) and comparable with rates in the more arid, dense brush regions farther north. Seroprevalence of adults was 28%, whereas that of children was significantly lower (3%; P < 0.001); the youngest positive child was age 3 years. Males were more likely to be seropositive than females (25% versus 11%; P < 0.01), and animal husbandry activities (birthing, sheltering, and butchering) were strongly associated with seropositivity. The results confirm that significant RVFV transmission occurs outside of recognized high-risk areas and independent of known epidemic periods.
很少有研究关注裂谷热病毒（RVFV）在已知高风险地区周边干旱程度较低的过渡地带的传播情况。本研究的目的是在裂谷热流行的加里萨地区边缘的一个林区博德黑村，确定裂谷热病毒暴露的证据。在2006年初疫情之间进行的一项基于家庭群组的调查中，招募了211名参与者。抗裂谷热病毒的总体血清阳性率很高（18%），与更北部干旱程度更高、植被茂密地区的比率相当。成年人的血清阳性率为28%，而儿童的血清阳性率则显著较低（3%；P<0.001）；最年幼的阳性儿童为3岁。男性血清阳性的可能性高于女性（25%对11%；P<0.01），畜牧活动（分娩、圈养和屠宰）与血清阳性密切相关。结果证实，裂谷热病毒在公认的高风险地区之外也有显著传播，且与已知的流行期无关。
