Virology Service, Centre Pasteur du Cameroun, 451 Rue 2005, Yaounde 2, P.O. Box 1274, Yaounde, Cameroon.
Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département de Virologie, Institut Pasteur, 28 Rue du Dr. Roux, F-75015, Paris, France.
Virol J. 2018 Apr 6;15(1):63. doi: 10.1186/s12985-018-0977-8.
Rift Valley Fever Phlebovirus (RVFV) and Crimean-Congo Hemorrhagic Fever Orthonairovirus (CCHFV) specific antibodies had been documented among humans in urban settings of the southwestern and northern Cameroon in the late 1980s. Recently, evidence for enzootic circulation of RVFV was reported among livestock in both rural and urban settings in Cameroon. However, current estimates of human exposure to RVFV and CCHFV are still to be documented in Cameroon, especially in rural areas. The aim of this study was to assess the seroprevalence of RVFV and CCHFV in rural settings in the Southeastern rain forest of Cameroon.
Using Enzyme-linked Immunosorbent Assays, the presence of RVFV and CCHFV Immunoglobulin G antibodies was investigated in plasma samples originating from 137 Pygmies from four villages of the East region of Cameroon. The studied population was found to be 12.4% (17/137) and 4.4% (6/137) seropositive for RVFV and CCHFV, respectively. The rates of RVFV IgG were comparable between the age groups and sex. Conversely, the rate of CCHFV IgG was significantly higher among the 41-60 years old participants (p = 0.02).
This study provides a substantial evidence of the circulation of RVFV and CCHFV among rural inhabitants of the East region of Cameroon.
1980 年代末，在喀麦隆西南部和北部的城市地区，已经有人类感染裂谷热丝状病毒（RVFV）和克里米亚-刚果出血热正呼肠孤病毒（CCHFV）的抗体的记录。最近，有证据表明 RVFV 在喀麦隆的农村和城市地区的牲畜中存在地方性循环。然而，目前仍需在喀麦隆记录人类接触 RVFV 和 CCHFV 的情况，特别是在农村地区。本研究旨在评估喀麦隆东南部热带雨林农村地区 RVFV 和 CCHFV 的血清流行率。
本研究使用酶联免疫吸附试验，对来自喀麦隆东部四个村庄的 137 名俾格米人血浆样本中的 RVFV 和 CCHFV 免疫球蛋白 G 抗体进行了检测。研究人群中 RVFV 和 CCHFV 的血清阳性率分别为 12.4%（17/137）和 4.4%（6/137）。RVFV IgG 的发生率在不同年龄组和性别之间没有差异。相反，41-60 岁组的 CCHFV IgG 发生率显著更高（p=0.02）。
本研究为 RVFV 和 CCHFV 在喀麦隆东部农村居民中的传播提供了重要证据。
