Corak A, Kapici S, Sercan C, Akkoç O, Ulucan K
Faculty of Dentistry, Department of Physiology, Marmara University, İstanbul, Turkey.
Faculty of Engineering and Natural Sciences, Department of Molecular Biology and Genetics, Üsküdar University, İstanbul, Turkey.
Cell Mol Biol (Noisy-le-grand). 2017 May 20;63(5):29-31. doi: 10.14715/cmb/2017.63.5.6.
We aimed to analyze the allelic distribution of solute carrier family-6 member-4 promoter region in Turkish athletes. Recent studies showed the association of lesser expressing "S" allele with anxiety. Genotype percentages for LL, LS and SS genotypes were found as 46, 35 and 19, respectively. 38% of the males had LL, %38 had LS and 24% had SS genotypes. Percentages of LL, LS and SS genotypes were 54, 31 and 15 in females, respectively. 15 (58%) male and 18 (69%) females had L, 11 (42%) male and 8 (31%) females had S alleles. Variations in the association of the SLC6A4 alleles with neuropsychiatric disorders according to different nationalities have been reported. This is the first report showing that LL genotype and L allele in Turkish athletes was more frequent than SS genotype and S allele.
我们旨在分析土耳其运动员溶质载体家族6成员4启动子区域的等位基因分布。最近的研究表明，低表达的“S”等位基因与焦虑有关。LL、LS和SS基因型的基因型百分比分别为46%、35%和19%。38%的男性具有LL基因型，38%具有LS基因型，24%具有SS基因型。女性中LL、LS和SS基因型的百分比分别为54%、31%和15%。15名（58%）男性和18名（69%）女性具有L等位基因，11名（42%）男性和8名（31%）女性具有S等位基因。据报道，SLC6A4等位基因与神经精神疾病的关联因不同国籍而有所差异。这是第一份表明土耳其运动员中LL基因型和L等位基因比SS基因型和S等位基因更常见的报告。
