Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA.
Immunology, Microenvironment & Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA. E-mail:
Zool Res. 2021 Mar 18;42(2):153-160. doi: 10.24272/j.issn.2095-8137.2020.382.
Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-related mortality in the developed world. EOC is a heterogeneous disease represented by several histological and molecular subtypes. Therefore, exploration of relevant preclinical animal models that consider the heterogenic nature of EOC is of great importance for the development of novel therapeutic strategies that can be translated clinically to combat this devastating disease. In this review, we discuss recent progress in the development of preclinical mouse models for EOC study as well as their advantages and limitations.
上皮性卵巢癌 (EOC) 是发达国家妇科癌症相关死亡的主要原因。EOC 是一种异质性疾病，由几种组织学和分子亚型代表。因此，探索考虑 EOC 异质性的相关临床前动物模型对于开发新的治疗策略以对抗这种毁灭性疾病具有重要意义。在本文中，我们讨论了用于 EOC 研究的临床前小鼠模型的最新进展及其优缺点。
