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格拉代尼戈综合征:一种常见感染引发罕见后果。

Gradenigo's syndrome: A common infection with uncommon consequences.

作者信息

Vitale Matthew, Amrit Misra, Arora Rajan, Lata Julie

机构信息

McLaren Macomb Hospital, Department of Emergency Medicine.

Children's Hospital of Michigan.

出版信息

Am J Emerg Med. 2017 Sep;35(9):1388.e1-1388.e2. doi: 10.1016/j.ajem.2017.07.020. Epub 2017 Jul 5.

DOI:10.1016/j.ajem.2017.07.020
PMID:28720403
Abstract

Acute otitis media is a common diagnosis encountered by emergency medicine providers. With appropriate antibiotic treatment, patients with otitis media, in general, have minimal long-term sequela from their underlying infection (Limb et al., 2017 [1]). However, untreated cases can develop life-threatening complications that require prompt intervention. We report a case of an 8-year-old that developed Gradenigo's syndrome, a condition characterized by the triad of otitis media, facial pain in the distribution of the trigeminal nerve, and abducens nerve palsy (Yeung and Lustig, 2016; Janjua et al., 2016; Kantas et al., 2010; Motamed and Kalan, n.d.; Vita Fooken Jensen et al., 2016 [2-6]). Signs and symptoms are often subtle, so a high-level of suspicion is required in order not to miss this potentially fatal process.

摘要

急性中耳炎是急诊医学从业者常遇到的一种诊断。一般来说,通过适当的抗生素治疗,中耳炎患者潜在感染的长期后遗症极少(林姆等人,2017 [1])。然而,未经治疗的病例可能会出现危及生命的并发症,需要及时干预。我们报告一例8岁儿童患Gradenigo综合征的病例,该综合征的特征为中耳炎、三叉神经分布区域的面部疼痛和展神经麻痹三联征(杨和卢斯蒂格,2016;詹朱亚等人,2016;坎塔斯等人,2010;莫塔梅德和卡兰,无日期;维塔·富肯·詹森等人,2016 [2 - 6])。其体征和症状往往很细微,因此需要高度怀疑,以免漏诊这一潜在的致命病症。

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1
Gradenigo's syndrome: A common infection with uncommon consequences.格拉代尼戈综合征:一种常见感染引发罕见后果。
Am J Emerg Med. 2017 Sep;35(9):1388.e1-1388.e2. doi: 10.1016/j.ajem.2017.07.020. Epub 2017 Jul 5.
2
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The Forgotten Syndrome? Four Cases of Gradenigo's Syndrome and a Review of the Literature.被遗忘的综合征?四例Gradenigo综合征及文献综述
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[Gradenigo's syndrome: a case-report].[格拉代尼戈综合征:一例报告]
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Gradenigo's syndrome with abscess of the petrous apex in pediatric patients: what is the best treatment?小儿Gradenigo综合征伴岩尖脓肿:最佳治疗方法是什么?
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Gradenigo's syndrome secondary to chronic otitis media on a background of previous radical mastoidectomy: a case report.既往行根治性乳突切除术后继发于慢性中耳炎的Gradenigo综合征:一例报告
J Med Case Rep. 2014 Jun 23;8:217. doi: 10.1186/1752-1947-8-217.
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[Otitis media, petrositis and Gradenigo's syndrome].[中耳炎、岩部炎及Gradenigo综合征]
Tijdschr Kindergeneeskd. 1989 Apr;57(2):63-6.

引用本文的文献

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The Diagnosis, Management, and Outcomes of Gradenigo Syndrome in Children: A Scoping Review of the Literature.儿童Gradenigo综合征的诊断、管理及预后:文献综述
Diagnostics (Basel). 2025 Aug 29;15(17):2193. doi: 10.3390/diagnostics15172193.
2
Gradenigo syndrome complicated by a retro-pharyngeal abscess in an 8-year-old child: A case report and literature review.一名8岁儿童并发咽后脓肿的Gradenigo综合征:病例报告及文献综述
Radiol Case Rep. 2025 Jan 17;20(4):1867-1870. doi: 10.1016/j.radcr.2024.12.054. eCollection 2025 Apr.
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Gradenigo Syndrome: A Case Report of a Rare Complication of Otitis Media.
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Cureus. 2024 Jan 8;16(1):e51865. doi: 10.7759/cureus.51865. eCollection 2024 Jan.
4
Fusobacterium necrophorum an Underrecognized Cause of Petrous Apicitis Presenting with Gradenigo Syndrome: A Case Report.败毒梭菌是岩尖炎伴 Gradenigo 综合征的一个被低估的病因:病例报告。
Am J Case Rep. 2024 Feb 6;25:e942652. doi: 10.12659/AJCR.942652.
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Imaging of Pathologies of the Temporal Bone and Middle Ear: Inflammatory Diseases, Their Mimics and Potential Complications-Pictorial Review.颞骨和中耳病变的影像学:炎症性疾病、其模拟疾病和潜在并发症——影像学综述。
Tomography. 2023 Dec 8;9(6):2190-2210. doi: 10.3390/tomography9060170.
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Gradenigo's syndrome with abscess of the petrous apex in pediatric patients: what is the best treatment?小儿Gradenigo综合征伴岩尖脓肿:最佳治疗方法是什么?
Childs Nerv Syst. 2019 Dec;35(12):2265-2272. doi: 10.1007/s00381-019-04352-4. Epub 2019 Aug 20.
7
Cross Sectional Imaging of the Ear and Temporal Bone.耳部及颞骨的横断面成像
Head Neck Pathol. 2018 Sep;12(3):302-320. doi: 10.1007/s12105-018-0901-y. Epub 2018 Aug 1.