Plodpai Yuvatiya, Hirunpat Siriporn, Kiddee Weerawat
Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla 90110, Thailand.
J Med Case Rep. 2014 Jun 23;8:217. doi: 10.1186/1752-1947-8-217.
Gradenigo's syndrome is nowadays a rare condition characterized by a triad of otorrhea, facial pain with trigeminal nerve involvement and abducens nerve palsy. Most cases are caused by medial extension of acute otitis media into a pneumatized petrous apex and surgical drainage is usually the treatment of choice. We present a case highlighting the pathological mechanism of this disease, demonstrate rare radiological findings associated with this patient, and showcase successful medical treatment without surgical intervention.
A 63-year-old Thai man presented with complete Gradenigo triad as a complication of chronic otomastoiditis in spite of clinical history of previous radical mastoidectomy and a nonpneumatization of the petrous apex. Magnetic resonance imaging showed abnormal prominent enhancement at the roof of his right temporal bone, and the dura overlying the floor of right middle cranial fossa and right cavernous sinus. Magnetic resonance imaging also detected right petrous apicitis. With the use of intravenous antibiotics and topical antibiotic eardrops, recovery was observed within 5 days with complete resolution within 2 months.
Although there is little evidence to support the use of medical therapy in the treatment of Gradenigo's syndrome resulting from chronic ear disease, we here demonstrate successful conservative treatment of Gradenigo's syndrome following chronic otitis media in a patient who underwent previous radical mastoidectomy.
Gradenigo综合征如今较为罕见,其特征为耳漏、伴有三叉神经受累的面部疼痛及展神经麻痹三联征。多数病例由急性中耳炎向气化的岩尖内侧蔓延所致,手术引流通常是首选治疗方法。我们报告一例病例,突出该疾病的病理机制,展示与该患者相关的罕见影像学表现,并展示无需手术干预的成功药物治疗。
一名63岁泰国男性尽管有既往根治性乳突切除术病史且岩尖无气化,但仍出现作为慢性中耳乳突炎并发症的完全性Gradenigo三联征。磁共振成像显示其右侧颞骨顶部、覆盖右侧中颅窝底和右侧海绵窦的硬脑膜有异常明显强化。磁共振成像还检测到右侧岩尖炎。通过静脉使用抗生素和局部使用抗生素耳滴剂,5天内观察到病情好转,2个月内完全恢复。
尽管几乎没有证据支持药物治疗用于因慢性耳部疾病导致的Gradenigo综合征,但我们在此展示了一名既往接受根治性乳突切除术的患者在慢性中耳炎后Gradenigo综合征的成功保守治疗。