• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

既往行根治性乳突切除术后继发于慢性中耳炎的Gradenigo综合征:一例报告

Gradenigo's syndrome secondary to chronic otitis media on a background of previous radical mastoidectomy: a case report.

作者信息

Plodpai Yuvatiya, Hirunpat Siriporn, Kiddee Weerawat

机构信息

Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla 90110, Thailand.

出版信息

J Med Case Rep. 2014 Jun 23;8:217. doi: 10.1186/1752-1947-8-217.

DOI:10.1186/1752-1947-8-217
PMID:24957520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4086707/
Abstract

INTRODUCTION

Gradenigo's syndrome is nowadays a rare condition characterized by a triad of otorrhea, facial pain with trigeminal nerve involvement and abducens nerve palsy. Most cases are caused by medial extension of acute otitis media into a pneumatized petrous apex and surgical drainage is usually the treatment of choice. We present a case highlighting the pathological mechanism of this disease, demonstrate rare radiological findings associated with this patient, and showcase successful medical treatment without surgical intervention.

CASE PRESENTATION

A 63-year-old Thai man presented with complete Gradenigo triad as a complication of chronic otomastoiditis in spite of clinical history of previous radical mastoidectomy and a nonpneumatization of the petrous apex. Magnetic resonance imaging showed abnormal prominent enhancement at the roof of his right temporal bone, and the dura overlying the floor of right middle cranial fossa and right cavernous sinus. Magnetic resonance imaging also detected right petrous apicitis. With the use of intravenous antibiotics and topical antibiotic eardrops, recovery was observed within 5 days with complete resolution within 2 months.

CONCLUSIONS

Although there is little evidence to support the use of medical therapy in the treatment of Gradenigo's syndrome resulting from chronic ear disease, we here demonstrate successful conservative treatment of Gradenigo's syndrome following chronic otitis media in a patient who underwent previous radical mastoidectomy.

摘要

引言

Gradenigo综合征如今较为罕见,其特征为耳漏、伴有三叉神经受累的面部疼痛及展神经麻痹三联征。多数病例由急性中耳炎向气化的岩尖内侧蔓延所致,手术引流通常是首选治疗方法。我们报告一例病例,突出该疾病的病理机制,展示与该患者相关的罕见影像学表现,并展示无需手术干预的成功药物治疗。

病例介绍

一名63岁泰国男性尽管有既往根治性乳突切除术病史且岩尖无气化,但仍出现作为慢性中耳乳突炎并发症的完全性Gradenigo三联征。磁共振成像显示其右侧颞骨顶部、覆盖右侧中颅窝底和右侧海绵窦的硬脑膜有异常明显强化。磁共振成像还检测到右侧岩尖炎。通过静脉使用抗生素和局部使用抗生素耳滴剂,5天内观察到病情好转,2个月内完全恢复。

结论

尽管几乎没有证据支持药物治疗用于因慢性耳部疾病导致的Gradenigo综合征,但我们在此展示了一名既往接受根治性乳突切除术的患者在慢性中耳炎后Gradenigo综合征的成功保守治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d4/4086707/b48837a60539/1752-1947-8-217-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d4/4086707/637c8d8e41ad/1752-1947-8-217-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d4/4086707/787b28244e36/1752-1947-8-217-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d4/4086707/b7252c1f6324/1752-1947-8-217-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d4/4086707/b48837a60539/1752-1947-8-217-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d4/4086707/637c8d8e41ad/1752-1947-8-217-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d4/4086707/787b28244e36/1752-1947-8-217-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d4/4086707/b7252c1f6324/1752-1947-8-217-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4d4/4086707/b48837a60539/1752-1947-8-217-4.jpg

相似文献

1
Gradenigo's syndrome secondary to chronic otitis media on a background of previous radical mastoidectomy: a case report.既往行根治性乳突切除术后继发于慢性中耳炎的Gradenigo综合征:一例报告
J Med Case Rep. 2014 Jun 23;8:217. doi: 10.1186/1752-1947-8-217.
2
Gradenigo's Syndrome in a Patient with Chronic Suppurative Otitis Media, Petrous Apicitis, and Meningitis.一名慢性化脓性中耳炎、岩尖炎和脑膜炎患者的Gradenigo综合征
Am J Case Rep. 2017 Sep 28;18:1039-1043. doi: 10.12659/ajcr.904648.
3
How well do we know Gradenigo? A comprehensive literature review and proposal for novel diagnostic categories of Gradenigo's syndrome.我们对 Gradenigo 综合征了解多少?一项全面的文献回顾及 Gradenigo 综合征新诊断类别的建议。
Int J Pediatr Otorhinolaryngol. 2020 May;132:109942. doi: 10.1016/j.ijporl.2020.109942. Epub 2020 Feb 8.
4
The changing face of petrous apicitis-a 40-year experience.岩尖炎的面貌变迁——40年经验总结
Laryngoscope. 2018 Jan;128(1):195-201. doi: 10.1002/lary.26571. Epub 2017 Apr 5.
5
Atypical Gradenigo's syndrome in a pediatric case: A critical review of neuroimaging.小儿非典型Gradenigo综合征病例:神经影像学的批判性综述
Radiol Case Rep. 2024 Apr 13;19(7):2633-2638. doi: 10.1016/j.radcr.2024.03.037. eCollection 2024 Jul.
6
Intracranial complications of acute otitis media and Gradenigo's syndrome.急性中耳炎的颅内并发症及Gradenigo综合征
B-ENT. 2013;9(2):151-6.
7
Gradenigo's syndrome in a four-year-old patient: a rare diagnosis in the modern antibiotic era.一名4岁患者的Gradenigo综合征:现代抗生素时代的罕见诊断。
J Laryngol Otol. 2019 Jun;133(6):535-537. doi: 10.1017/S0022215119001026. Epub 2019 May 28.
8
Gradenigo's syndrome: A common infection with uncommon consequences.格拉代尼戈综合征:一种常见感染引发罕见后果。
Am J Emerg Med. 2017 Sep;35(9):1388.e1-1388.e2. doi: 10.1016/j.ajem.2017.07.020. Epub 2017 Jul 5.
9
Gradenigo's syndrome with abscess of the petrous apex in pediatric patients: what is the best treatment?小儿Gradenigo综合征伴岩尖脓肿:最佳治疗方法是什么?
Childs Nerv Syst. 2019 Dec;35(12):2265-2272. doi: 10.1007/s00381-019-04352-4. Epub 2019 Aug 20.
10
[Isolated apical petrositis: an atypical case of Gradenigo's syndrome].[孤立性岩尖炎:Gradenigo综合征的非典型病例]
HNO. 2007 Mar;55(3):206-10. doi: 10.1007/s00106-006-1399-2.

引用本文的文献

1
A Rare Case of Abducens Nerve Palsy Caused by Primary Squamous Cell Carcinoma of the Middle Ear.中耳原发性鳞状细胞癌导致展神经麻痹1例罕见病例
Neuroophthalmology. 2024 Jun 12;48(5):373-376. doi: 10.1080/01658107.2024.2336240. eCollection 2024.
2
Refractory Pseudomonas Osteomyelitis of the Skull Base With Gradenigo's Syndrome: Early Dysphagia and Late Abducens Nerve Palsy.伴有Gradenigo综合征的颅底难治性铜绿假单胞菌骨髓炎:早期吞咽困难和晚期展神经麻痹
J Med Cases. 2024 Apr;15(2-3):43-48. doi: 10.14740/jmc4191. Epub 2024 Apr 8.
3
[Sudden-onset double vision-a complication requiring interdisciplinary treatment].

本文引用的文献

1
Conservative management of Gradenigo's syndrome in a child.儿童Gradenigo综合征的保守治疗
BMJ Case Rep. 2011 Apr 19;2011:bcr0320113978. doi: 10.1136/bcr.03.2011.3978.
2
Gradenigo's Syndrome: Beyond the Classical Triad of Diplopia, Facial Pain and Otorrhea.格拉代尼戈综合征:超越复视、面部疼痛和耳漏的经典三联征。
Case Rep Neurol. 2011 Feb 15;3(1):45-7. doi: 10.1159/000324179.
3
Acute otitis media-induced petrous apicitis presenting as the Gradenigo syndrome: successfully treated by ventilation tube insertion.急性中耳炎引起的岩尖炎表现为 Gradenigo 综合征:经通气管插入治疗成功。
[突发复视——一种需要多学科治疗的并发症]
HNO. 2024 Nov;72(11):825-828. doi: 10.1007/s00106-024-01450-x. Epub 2024 Mar 18.
4
Fusobacterium necrophorum an Underrecognized Cause of Petrous Apicitis Presenting with Gradenigo Syndrome: A Case Report.败毒梭菌是岩尖炎伴 Gradenigo 综合征的一个被低估的病因:病例报告。
Am J Case Rep. 2024 Feb 6;25:e942652. doi: 10.12659/AJCR.942652.
5
Gradenigo's Syndrome With Septic Lateral Sinus Thrombosis.伴有化脓性横窦血栓形成的Gradenigo综合征
Cureus. 2023 Feb 9;15(2):e34797. doi: 10.7759/cureus.34797. eCollection 2023 Feb.
6
An Atypical Radiologic Presentation of Right Sixth Lateral Rectus Palsy: A Case Report.右侧外直肌麻痹的非典型影像学表现:一例报告
Cureus. 2022 Dec 16;14(12):e32597. doi: 10.7759/cureus.32597. eCollection 2022 Dec.
7
Petrositis caused by fluconazole-resistant candida: case report and literature review.氟康唑耐药念珠菌引起的类鼻疽:病例报告及文献复习。
BMC Infect Dis. 2022 Jul 27;22(1):649. doi: 10.1186/s12879-022-07637-3.
8
Steroid-Responsive Gradenigo's Syndrome Mimicking Subdural Hematoma.模仿硬膜下血肿的类固醇反应性Gradenigo综合征
Cureus. 2021 Nov 13;13(11):e19547. doi: 10.7759/cureus.19547. eCollection 2021 Nov.
9
Unusual manifestation of Koch's disease: Gradenigo-Lannois syndrome.罕见的 Koch 病表现:Gradenigo-Lannois 综合征。
BMJ Case Rep. 2020 Nov 2;13(11):e236779. doi: 10.1136/bcr-2020-236779.
10
Headache in Petrous Apicitis: A Case Report of Chronic Migraine-like Headache Due to Peripheral Pathology.岩尖部病变性头痛:一例因周围性病变引起的慢性偏头痛样头痛病例报告。
Headache. 2019 Nov;59(10):1821-1826. doi: 10.1111/head.13643. Epub 2019 Sep 18.
Am J Otolaryngol. 2011 Sep-Oct;32(5):445-7. doi: 10.1016/j.amjoto.2010.07.018. Epub 2010 Oct 2.
4
Diffusion-weighted MRI identifies petrous apex abscess in Gradenigo syndrome.弥散加权 MRI 可识别 Gradenigo 综合征中的岩尖脓肿。
J Neuroophthalmol. 2010 Mar;30(1):34-6. doi: 10.1097/WNO.0b013e3181c5d0fd.
5
Gradenigo's syndrome with lateral venous sinus thrombosis: successful conservative treatment.伴有外侧窦静脉血栓形成的 Gradenigo 综合征:成功的保守治疗。
Eur J Pediatr. 2010 Apr;169(4):437-40. doi: 10.1007/s00431-009-1047-4. Epub 2009 Aug 21.
6
Gradenigo syndrome without acute otitis media.无急性中耳炎的Gradenigo综合征。
Pediatr Neurol. 2009 Sep;41(3):215-9. doi: 10.1016/j.pediatrneurol.2009.03.008.
7
Gradenigo's syndrome.格拉代尼戈综合征
J Emerg Med. 2010 May;38(4):449-51. doi: 10.1016/j.jemermed.2007.08.074. Epub 2008 Mar 4.
8
Gradenigo's syndrome: successful conservative treatment in adult and paediatric patients.格拉代尼戈综合征:成人和儿童患者保守治疗成功案例
J Laryngol Otol. 2005 Apr;119(4):325-9. doi: 10.1258/0022215054020313.
9
Gradenigo syndrome: a rare but serious complication of otitis media.格拉代尼戈综合征:中耳炎一种罕见但严重的并发症。
Pediatr Emerg Care. 2005 Jun;21(6):384-6. doi: 10.1097/01.pec.0000166731.70847.d5.
10
Conservative management of Gradenigo syndrome in a child.儿童Gradenigo综合征的保守治疗
Int J Pediatr Otorhinolaryngol. 2001 Jan;57(1):79-83. doi: 10.1016/s0165-5876(00)00442-0.