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小儿Gradenigo综合征伴岩尖脓肿:最佳治疗方法是什么?

Gradenigo's syndrome with abscess of the petrous apex in pediatric patients: what is the best treatment?

作者信息

Savasta Salvatore, Canzi Pietro, Aprile Federico, Michev Alexandre, Foiadelli Thomas, Manfrin Marco, Benazzo Marco

机构信息

Pediatric Clinic, IRCCS Policlinico "S. Matteo" Foundation, University of Pavia, Pavia, Italy.

Department of Otorhinolaryngology, IRCCS Policlinico "S. Matteo" Foundation, University of Pavia, Pavia, Italy.

出版信息

Childs Nerv Syst. 2019 Dec;35(12):2265-2272. doi: 10.1007/s00381-019-04352-4. Epub 2019 Aug 20.

Abstract

BACKGROUND

Gradenigo's syndrome is defined by the classic clinical triad of ear discharge, trigeminal pain, and abducens nerve palsy. It has become a very rare nosological entity after the introduction of antibiotics, so that has been defined as the "forgotten syndrome." However, the underlying pathological process (apical petrositis) still represents a life-threatening condition that shall be immediately recognized in order to address the patient to the proper therapy. The therapy itself may be an argument of discussion: on a historical background ruled by surgery, reports of successful conservative antibiotic treatment have risen in recent years.

METHODS AND RESULTS

We reported a case of Gradenigo's syndrome in a child with an abscess of the left petrous apex and initial involvement of the carotid artery. After multidisciplinary evaluation, we decided to encourage conservative treatment, until complete regression was observed.

DISCUSSION

The available literature of the last 10 years was reviewed, with particular attention to the presence of an apical abscess and the therapeutic approach. The principles of management with regard to conservative therapy versus surgical indications are therefore examined and discussed.

摘要

背景

Gradenigo综合征由耳漏、三叉神经痛和展神经麻痹这一经典临床三联征定义。在抗生素问世后,它已成为一种非常罕见的病种,因此被定义为“被遗忘的综合征”。然而,潜在的病理过程(岩尖炎)仍然是一种危及生命的状况,必须立即识别,以便为患者提供适当的治疗。治疗方法本身可能存在争议:在以手术为主导的历史背景下,近年来成功的保守抗生素治疗报告有所增加。

方法与结果

我们报告了一例患有左侧岩尖脓肿且颈动脉最初受累的儿童Gradenigo综合征病例。经过多学科评估后,我们决定采用保守治疗,直至观察到完全消退。

讨论

回顾了过去10年的现有文献,特别关注岩尖脓肿的存在及治疗方法。因此,对保守治疗与手术指征的管理原则进行了审查和讨论。

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