Smelov Vitaly, Hanisch Rachel, McKay-Chopin Sandrine, Sokolova Olga, Eklund Carina, Komyakov Boris, Gheit Tarik, Tommasino Massimo
Infections and Cancer Biology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France; Screening Group, International Agency for Research on Cancer, World Health Organization, Lyon, France; Department of Urology, North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia; Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Section of Environment and Radiation, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Papillomavirus Res. 2017 Jun;3:66-72. doi: 10.1016/j.pvr.2017.02.002. Epub 2017 Feb 16.
Data regarding anal cutaneous HPV detection among HIV-positive and HIV-negative persons largely relies on studies among men who have sex with men in limited geographical settings. Understanding the distribution, determinants, and potential human health effects of anal cutaneous HPV types among men who have sex with women (MSW) is important.
Anal canal swab samples from 415 Russian MSW (384 HIV-negative and 31 HIV-positive) were tested for 43 β-HPVs and 29 γ-HPVs, using a multiplex PCR combined with Luminex technology.
β-HPV was detected in 24.4% and γ-HPV in 15.9% of anal samples of all Russian MSW. In total, 34 β-HPV and 19 γ-HPV types were detected, with the most commonly detected β-HPV types being 110, 22 and 124 and the most common γ-HPV types being 95, 132 and 50. For both genera, being HIV-positive at the time of testing was a significant determinant of detection (74.2% for β-HPVs and 48.4% for γ-HPVs compared to 20.1% and 12.5% in HIV-negative MSW, respectively).
A wide spectrum and moderate prevalence of anal β-HPV and γ-HPV types was found in our MSW study sample, suggesting that routes other than penile-anal intercourse may be important in cutaneous HPV transmission.
关于HIV阳性和HIV阴性人群肛门皮肤HPV检测的数据，很大程度上依赖于在有限地理区域内对男男性行为者的研究。了解与女性发生性行为的男性（MSW）中肛门皮肤HPV类型的分布、决定因素及对人类健康的潜在影响非常重要。
使用多重PCR结合Luminex技术，对415名俄罗斯MSW（384名HIV阴性和31名HIV阳性）的肛管拭子样本进行了43种β - HPV和29种γ - HPV检测。
在所有俄罗斯MSW的肛门样本中，24.4%检测到β - HPV，15.9%检测到γ - HPV。总共检测到34种β - HPV和19种γ - HPV类型，最常检测到的β - HPV类型为110、22和124，最常见的γ - HPV类型为95、132和50。对于这两个属，检测时HIV呈阳性是检测的一个重要决定因素（β - HPV为74.2%，γ - HPV为48.4%，而HIV阴性MSW中分别为20.1%和12.5%）。
在我们的MSW研究样本中发现肛门β - HPV和γ - HPV类型具有广泛的谱系和中等患病率，这表明除阴茎 - 肛门性交之外的传播途径可能在皮肤HPV传播中很重要。
