Torres Montserrat, Gheit Tarik, McKay-Chopin Sandrine, Rodríguez Carmen, Romero Jorge Del, Filotico Raffaele, Doná Maria Gabriella, Ortiz Marta, Tommasino Massimo
Infections and Cancer Biology Group, International Agency for Research on Cancer, 69008 Lyon, France.
Sandoval Health Centre, ES-28029 Madrid, Spain.
J Clin Virol. 2015 Jun;67:47-51. doi: 10.1016/j.jcv.2015.04.005. Epub 2015 Apr 8.
Mucosal high-risk human papillomavirus (HPV) types benefit differently from the immunocompromised status of the host. So far it is not known whether a similar scenario holds for the large group of the β and γ cutaneous HPV types that appear to be present at several anatomical sites.
The presence of β (n=43) and γ (n=30) HPVs in the anal samples of 66 HIV-positive and 153 HIV-negative anonymized men who have sex with men (MSM) was determined by multiplex PCR, using type-specific primers and bead-based hybridization (Luminex technology).
The prevalence of β and γ HPV infection was 65.6% and 68.2%, respectively, among HIV-positive MSM and 59.1% and 57.7%, respectively, among HIV-negative MSM. β-2 and γ-10 were found to be the most prevalent species in both groups. The prevalence of infection with HPV types of the species β-1 (P=0.02), β-3 (P=0.002), γ-6 (P=0.002), and γ-7 (P=0.02) was higher in HIV-positive than HIV-negative men. In contrast, the β-2 species was equally distributed in the two groups, while the γ-10 species was slightly affected by HIV status.
These findings provide evidence that impairment of the host's immune surveillance impacts β and γ HPV infections differently.
黏膜高危型人乳头瘤病毒（HPV）类型从宿主免疫功能低下状态中获益的方式有所不同。目前尚不清楚对于似乎存在于多个解剖部位的大量β和γ皮肤型HPV类型，是否也存在类似情况。
通过多重聚合酶链反应（PCR），使用型特异性引物和基于磁珠的杂交技术（Luminex技术），检测了66名感染人类免疫缺陷病毒（HIV）呈阳性和153名HIV呈阴性的男男性行为者（MSM）肛门样本中β（n = 43）和γ（n = 30）HPV的存在情况。
在HIV阳性的MSM中，β和γHPV感染率分别为65.6%和68.2%，在HIV阴性的MSM中分别为59.1%和57.7%。β-2和γ-10被发现是两组中最常见的类型。HIV阳性男性中β-1（P = 0.02）、β-3（P = 0.002）、γ-6（P = 0.002）和γ-7（P = 0.02）型HPV的感染率高于HIV阴性男性。相比之下，β-2类型在两组中分布均匀，而γ-10类型受HIV状态的影响较小。
这些发现提供了证据，表明宿主免疫监视功能受损对β和γHPV感染的影响不同。
