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Different modes of enhancer-specific regulation by Runt and Even-skipped during segmentation.在胚胎分节过程中，Runt和Even-skipped对增强子特异性调控的不同模式。
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Morphogen rules: design principles of gradient-mediated embryo patterning.形态发生素规则：梯度介导的胚胎模式形成的设计原则
Development. 2015 Dec 1;142(23):3996-4009. doi: 10.1242/dev.129452.
3
Zelda overcomes the high intrinsic nucleosome barrier at enhancers during Drosophila zygotic genome activation.在果蝇合子基因组激活过程中，塞尔达克服了增强子处高度内在的核小体障碍。
Genome Res. 2015 Nov;25(11):1703-14. doi: 10.1101/gr.192542.115. Epub 2015 Sep 2.
4
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Four-way regulation of mosquito yolk protein precursor genes by juvenile hormone-, ecdysone-, nutrient-, and insulin-like peptide signaling pathways.保幼激素、蜕皮激素、营养物质和胰岛素样肽信号通路对蚊虫卵黄蛋白前体基因的四重调控
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广泛表达的阻遏物整合胚胎中正交轴上的模式形成。

Broadly expressed repressors integrate patterning across orthogonal axes in embryos.

作者信息

Koromila Theodora, Stathopoulos Angelike

机构信息

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125

出版信息

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8295-8300. doi: 10.1073/pnas.1703001114. Epub 2017 Jul 18.

DOI:10.1073/pnas.1703001114
PMID:28720706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5547611/
Abstract

The role of spatially localized repressors in supporting embryonic patterning is well appreciated, but, alternatively, the role ubiquitously expressed repressors play in this process is not well understood. We investigated the function of two broadly expressed repressors, Runt (Run) and Suppressor of Hairless [Su(H)], in patterning the embryo. Previous studies have shown that Run and Su(H) regulate gene expression along anterior-posterior (AP) or dorsal-ventral (DV) axes, respectively, by spatially limiting activator action, but here we characterize a different role. Our data show that broadly expressed repressors silence particular enhancers within -regulatory systems, blocking their expression throughout the embryo fully but transiently, and, in this manner, regulate spatiotemporal outputs along both axes. Our results suggest that Run and Su(H) regulate the temporal action of enhancers and are not dedicated regulators of one axis but, instead, act coordinately to pattern both axes, AP and DV.

摘要

空间定位的阻遏物在支持胚胎模式形成中的作用已得到充分认识，但普遍表达的阻遏物在此过程中所起的作用却尚未得到很好的理解。我们研究了两种广泛表达的阻遏物Runt（Run）和无翅毛蛋白（Su(H)）在胚胎模式形成中的功能。先前的研究表明，Run和Su(H)分别通过在空间上限制激活因子的作用来调节沿前后轴（AP）或背腹轴（DV）的基因表达，但在此我们描述了一种不同的作用。我们的数据表明，广泛表达的阻遏物使调控系统内的特定增强子沉默，完全但短暂地阻断其在整个胚胎中的表达，并以这种方式调节沿两个轴的时空输出。我们的结果表明，Run和Su(H)调节增强子的时间作用，并非专门调节一个轴，而是协同作用以形成AP和DV两个轴的模式。