Barone P, Davis T A, Braun A R, Chase T N
Eur J Pharmacol. 1986 Apr 9;123(1):109-14. doi: 10.1016/0014-2999(86)90694-1.
The effect of selective D-1 and D-2 dopamine receptor agonists (SKF 38393 and LY 171555, respectively) on motor function was studied in rats with unilateral, quinolinic acid-induced striatal lesions. Dose-dependent turning ipsilateral to the side of the lesion was elicited by LY 171555, but not by SKF 38393. When the drugs were given together, however, SKF 38393 was able to increase the total number (but not the duration) of turning induced by LY 171555 in a dose-dependent fashion. Furthermore, either alpha-methyl-paratyrosine pretreatment, a DA-depleting agent, or SCH 23390, a D-1 antagonist, inhibited the LY 171555-induced rotation, which would be restored by SKF 38393. These observations suggest that both the D-1 and D-2 dopamine receptor systems participate in the regulation of rotational behaviors in striatally lesioned rats with normosensitive DA receptors.
分别使用选择性D-1和D-2多巴胺受体激动剂（分别为SKF 38393和LY 171555）对单侧喹啉酸诱导纹状体损伤的大鼠的运动功能进行了研究。LY 171555可引起向损伤侧同侧的剂量依赖性旋转，但SKF 38393则不能。然而，当将这两种药物一起给药时，SKF 38393能够以剂量依赖性方式增加LY 171555诱导的旋转总数（但不增加持续时间）。此外，多巴胺耗竭剂α-甲基对酪氨酸预处理或D-1拮抗剂SCH 23390均可抑制LY 171555诱导的旋转，而SKF 38393可使其恢复。这些观察结果表明，D-1和D-2多巴胺受体系统均参与了具有正常敏感性多巴胺受体的纹状体损伤大鼠旋转行为的调节。
