Stacey Glyn N, Connon Che J, Coopman Karen, Dickson Alan J, Fuller Barry, Hunt Charles J, Kemp Paul, Kerby Julie, Man Jennifer, Matejtschuk Paul, Moore Harry, Morris John, Oreffo Richard Oc, Slater Nigel, Ward Stephen, Wiggins Claire, Zimmermann Heiko
UK Stem Cell Bank, Division of Advanced Therapies, NIBSC, South Mimms, Hertfordshire, UK.
Institute of Genetic Medicine, University of Newcastle, Newcastle upon Tyne, UK.
Regen Med. 2017 Jul;12(5):553-564. doi: 10.2217/rme-2017-0073. Epub 2017 Jul 19.
If the field of regenerative medicine is to deliver therapies, rapid expansion and delivery over considerable distances to large numbers of patients is needed. This will demand efficient stabilization and shipment of cell products. However, cryopreservation science is poorly understood by life-scientists in general and in recent decades only limited progress has been made in the technology of preservation and storage of cells. Rapid translation of new developments to a broader range of cell types will be vital, as will assuring a deeper knowledge of the fundamental cell biology relating to successful preservation and recovery of cell cultures. This report presents expert consensus on these and other issues which need to be addressed for more efficient delivery of cell therapies.
如果再生医学领域要提供治疗方法，就需要对大量患者进行快速扩增并远距离输送。这将要求高效地稳定保存和运输细胞产品。然而，一般生命科学家对冷冻保存科学了解甚少，并且近几十年来，细胞保存和储存技术仅取得了有限的进展。将新进展迅速转化应用于更广泛的细胞类型至关重要，确保更深入了解与细胞培养物成功保存和复苏相关的基础细胞生物学知识也同样重要。本报告就这些以及为更有效地提供细胞疗法需要解决的其他问题提出了专家共识。
