La Paglia Giuliana Maria Concetta, Leone Maria Comasia, Lepri Gemma, Vagelli Roberta, Valentini Eleonora, Alunno Alessia, Tani Chiara
Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Florence, AOUC, Florence, Italy.
Clin Exp Rheumatol. 2017 Jul-Aug;35(4):551-561. Epub 2017 Jul 11.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that predominately affects women. It is characterised by a broad spectrum of clinical manifestations, however, its course and organ involvement are unpredictable. Although over the last few decades an improvement in survival for SLE patients has been observed, pathogenic mechanisms underlying this disease are still unclear. Comorbidities, due to both disease and treatment, as well as multiple aspects of SLE, are under intensive investigation. Following the previous annual reviews of this series, we hereby provide a critical digest of the recent papers on SLE focusing on pathogenesis, clinical and laboratory features, as well as current and new therapeutic strategies published over the last year.
系统性红斑狼疮（SLE）是一种主要影响女性的慢性自身免疫性疾病。其临床表现多种多样，然而，其病程和器官受累情况难以预测。尽管在过去几十年中观察到SLE患者的生存率有所提高，但该疾病的发病机制仍不清楚。由于疾病和治疗导致的合并症以及SLE的多个方面都在深入研究中。继本系列之前的年度综述之后，我们在此提供对近期关于SLE的论文的批判性摘要，重点关注发病机制、临床和实验室特征，以及过去一年发表的当前和新的治疗策略。
