Mirabelli Giulia, Cannarile Francesca, Bruni Cosimo, Vagelli Roberta, De Luca Rossella, Carli Linda
Department of Rheumatology, University of Perugia, Perugia, Italy.
Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy.
Clin Exp Rheumatol. 2015 May-Jun;33(3):414-25. Epub 2015 Jun 22.
Systemic lupus erythematosus is a multiorgan autoimmune disease with a highly variable clinical course, typically involving women in childbearing age. At present, many aspects of its pathogenesis still remain unclear. Moreover, although a significant increase of patient survival has been observed in the last decades, morbidity and mortality remain high. Finally, SLE impacts negatively on the health-related quality-of-life of patients. Therefore, multiple aspects of SLE still remain challenging and it continues to be the object of both clinical and translational clinical research. Herewith, we provide a critical digest of the recent literature on this topic.
系统性红斑狼疮是一种多器官自身免疫性疾病，临床病程高度可变，典型地累及育龄女性。目前，其发病机制的许多方面仍不清楚。此外，尽管在过去几十年中观察到患者生存率显著提高，但发病率和死亡率仍然很高。最后，系统性红斑狼疮对患者与健康相关的生活质量产生负面影响。因此，系统性红斑狼疮的多个方面仍然具有挑战性，并且它仍然是临床和转化临床研究的对象。在此，我们提供关于该主题的近期文献的批判性摘要。
