Shen Chang-Xing, Tan Min, Song Xiao-Lian, Xie Shuan-Shuan, Zhang Guo-Liang, Wang Chang-Hui
Shanghai Tenth People's Hospital, Shanghai, China.
Medicine (Baltimore). 2017 Jul;96(29):e7320. doi: 10.1097/MD.0000000000007320.
Red blood cell distribution width (RDW) is a risk factor for the complications caused by obstructive sleep apnea hypopnea syndrome (OSAHS). This study was aimed to evaluate the predictive value of RDW for the occurrence of cerebral infarction in patients with OSAHS.We conducted a prospective study of 129 consecutive patients who were admitted to the Sleep Laboratory of in the Tenth People's Hospital of Shanghai (China) with complaints of snoring, apnea, or daytime sleepiness. All patients underwent polysomnography between June 2011 and May 2012. In total, 90 patients met the study criteria and were included in the study; there are 71 men and 19 women.RDW correlated positively with the apnea hypopnea index (AHI) (P = .00, r = 0.76). Logistic regression analysis showed correlations between each variation and cerebral infarction, high blood pressure (odds ratio [OR] = 4.72, P = .220), diabetes (OR = 2.67, P = .490), hyperlipidemia (OR = 7.42, P = .190), RDW (OR = 58.24, P = .020), and AHI (OR = 243.92, P = .001). RDW ≥ 15% showed a higher predictive value for the occurrence of cerebral infarction in patients with OSAHS (area under curve 0.837; sensitivity 0.919; specificity 0.755), with positive and negative predictive values of 0.697 and 0.938, respectively.RDW correlates positively with AHI. RDW values ≥15% are predictive for the occurrence of cerebral infarction in patients with OSAHS.
红细胞分布宽度（RDW）是阻塞性睡眠呼吸暂停低通气综合征（OSAHS）所致并发症的一个危险因素。本研究旨在评估RDW对OSAHS患者发生脑梗死的预测价值。我们对连续129例因打鼾、呼吸暂停或日间嗜睡而入住上海第十人民医院睡眠实验室的患者进行了一项前瞻性研究。所有患者于2011年6月至2012年5月期间接受了多导睡眠监测。共有90例患者符合研究标准并被纳入研究；其中男性71例，女性19例。RDW与呼吸暂停低通气指数（AHI）呈正相关（P = 0.00，r = 0.76）。逻辑回归分析显示各变量与脑梗死、高血压（比值比[OR]=4.72，P = 0.220）、糖尿病（OR = 2.67，P = 0.490）、高脂血症（OR = 7.42，P = 0.190）、RDW（OR = 58.24，P = 0.020）和AHI（OR = 243.92，P = 0.001）之间存在相关性。RDW≥15%对OSAHS患者发生脑梗死具有较高的预测价值（曲线下面积为0.837；敏感性为0.919；特异性为0.755），阳性预测值和阴性预测值分别为0.697和0.938。RDW与AHI呈正相关。RDW值≥15%可预测OSAHS患者发生脑梗死。
