Tunis Med. 2022;100(6):445-449.
Obstructive sleep apnea syndrome (OSAS) is associated with cardiovascular disease (CVD). Red blood cell distribution width (RDW) is reported as a novel marker of cardiovascular disease (CVD) risk. We aimed to investigate the correlation of RDW level with the severity of Obstructive Sleep Apnea Syndrome (OSAS) defined with the apnea-hypopnea index (AHI) and to study the relationship between RDW and CVD in OSAS.
From retrospective analyses of patients admitted to our department for polygraphy between January 2018 and January 2020, OSAS patients with complete medical records and hemogram analyses were evaluated.
The study population consisted of 160 patients (101 females/59 males). The mean age was 52.32 ± 10.83 years. RDW correlated positively with the apnea hypopnea index (AHI) (r=0.392; p < 0.0001) and C-reactive protein (CRP) (r = 0.3, p < 0.001). RDW and CRP were significantly higher in patients with CVD than whom without CVD (p < 0.0001). In multivariate analysis, the independent predictors of CVD in OSAS were RDW (p < 0.0001; OR=3.095; CI: 1.69-5.66), CRP (p=0.046; OR=1.136; CI: 1.002-1.287) and age (p=0.013; OR=1.085; CI: 1.017- 1.157). The cut-off level for RDW with optimal sensitivity and specificity was calculated as 14.45 with sensitivity of 81% and specificity of 75%.
The findings of this study suggest that RDW, a simple, relatively inexpensive and universally available marker could have the ability to predict CVD in OSAS.
阻塞性睡眠呼吸暂停综合征（OSAS）与心血管疾病（CVD）相关。红细胞分布宽度（RDW）被报道为心血管疾病（CVD）风险的新型标志物。我们旨在研究 RDW 水平与阻塞性睡眠呼吸暂停综合征（OSAS）严重程度的相关性，该严重程度由呼吸暂停-低通气指数（AHI）定义，并研究 RDW 与 OSAS 中的 CVD 的关系。
从 2018 年 1 月至 2020 年 1 月期间在我们部门进行多导睡眠图检查的患者的回顾性分析中，评估了具有完整病历和血液分析的 OSAS 患者。
研究人群包括 160 名患者（101 名女性/59 名男性）。平均年龄为 52.32 ± 10.83 岁。RDW 与呼吸暂停低通气指数（AHI）呈正相关（r=0.392；p < 0.0001）和 C 反应蛋白（CRP）（r = 0.3，p < 0.001）。与无 CVD 的患者相比，CVD 患者的 RDW 和 CRP 显著升高（p < 0.0001）。在多变量分析中，OSAS 中 CVD 的独立预测因子是 RDW（p < 0.0001；OR=3.095；CI：1.69-5.66）、CRP（p=0.046；OR=1.136；CI：1.002-1.287）和年龄（p=0.013；OR=1.085；CI：1.017-1.157）。RDW 的最佳灵敏度和特异性的截断值水平计算为 14.45，灵敏度为 81%，特异性为 75%。
本研究的结果表明，RDW 作为一种简单、相对便宜且普遍可用的标志物，可能有能力预测 OSAS 中的 CVD。
