Department of Psychiatry, National Center for Mental Health, Seoul, Republic of Korea.
Medical Research Center, Institute of Human Behavioral Medicine, Seoul National University, Seoul, Republic of Korea.
Neurobiol Aging. 2022 Feb;110:88-95. doi: 10.1016/j.neurobiolaging.2021.10.005. Epub 2021 Oct 14.
This study aimed to explore the moderating effects of the frequently used cognitive reserve (CR) proxies [i.e., education, premorbid intelligence quotient (pIQ), occupational complexity (OC), and lifetime cognitive activity (LCA)] on the relationships between various in vivo Alzheimer's disease (AD) pathologies and cognition. In total, 351 [268 cognitively unimpaired (CU), 83 cognitive impaired (CI)] older adults underwent multi-modal brain imaging to measure AD pathologies and cognitive assessments, and information on CR proxies was obtained. For overall participants, only education moderated the relationship between Aβ deposition and cognition. Education, pIQ, and LCA, but not OC, showed moderating effect on the relationship between AD-signature cerebral hypometabolism and cognition. In contrast, only OC had a moderating effect on the relationship between cortical atrophy of the AD-signature regions and cognition. Such moderation effects of the CR proxies were similarly observed in CI individuals, but most of them were not in CU individuals. The findings suggest that the proposed CR proxies have different moderating effects on the relationships between specific AD pathologies and cognition.
本研究旨在探讨常用认知储备（CR）指标[即教育、发病前智商（pIQ）、职业复杂性（OC）和终生认知活动（LCA）]对各种体内阿尔茨海默病（AD）病理学与认知之间关系的调节作用。共有 351 名[268 名认知正常（CU），83 名认知障碍（CI）]老年人接受了多模态脑成像以测量 AD 病理学和认知评估，并获得了 CR 指标的信息。对于所有参与者，只有教育调节了 Aβ沉积与认知之间的关系。教育、pIQ 和 LCA，但不是 OC，对 AD 特征性脑代谢低下与认知之间的关系具有调节作用。相反，只有 OC 对 AD 特征区域皮质萎缩与认知之间的关系具有调节作用。CR 指标的这种调节作用在 CI 个体中也有类似的观察，但在 CU 个体中大多数并不明显。研究结果表明，所提出的 CR 指标对特定 AD 病理学与认知之间的关系具有不同的调节作用。
