Physics Institute, Goethe University Frankfurt am Main, 60438, Frankfurt am Main, Germany.
Department of Electronics Technology, Universidad Carlos III de Madrid, Leganes, Madrid, 28911, Spain.
Sci Rep. 2017 Jul 19;7(1):5822. doi: 10.1038/s41598-017-06034-0.
The pathological skin phenotype caused by hyperglycemia is an important indicator for the progress of diabetes mellitus. An early detection of diabetes assures an early intervention to regulate the carbohydrate metabolism. In this publication a non-invasive detection principle based on the measurement of complex scattering parameters in the millimeter-wave frequency range is presented. The measurement principle provides evidence of the applicability for the identification of different glycemic states in animal models. The method proposed here can be used to predict diabetes status in animal models and is interesting for application on humans in view of safeness of millimeter-wave radiation. Furthermore the complex scattering parameters give important information about the anatomic varieties between the analyzed skin samples of the different mice strains. In contrast to other methods, our approach is less sensitive to skin variations between animals.
高血糖引起的病理性皮肤表型是糖尿病进展的一个重要指标。早期发现糖尿病可以保证早期进行干预来调节碳水化合物代谢。本文提出了一种基于测量毫米波频率范围内的复散射参数的非侵入性检测原理。该测量原理为在动物模型中识别不同血糖状态的适用性提供了证据。这里提出的方法可用于预测动物模型中的糖尿病状态，并且鉴于毫米波辐射的安全性，对人类应用也很有意义。此外，复散射参数提供了有关不同小鼠品系的分析皮肤样本之间的解剖差异的重要信息。与其他方法相比，我们的方法对动物之间的皮肤差异不太敏感。
