Holzapfel B M, Rudert M, Hutmacher D W
Orthopädische Klinik König-Ludwig Haus, Julius-Maximilians Universität Würzburg, Brettreichstr. 11, 97074, Würzburg, Deutschland.
Centre for Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, QLD 4049, Brisbane, Australia.
Orthopade. 2017 Aug;46(8):701-710. doi: 10.1007/s00132-017-3444-0.
Tissue engineering provides the possibility of regenerating damaged or lost osseous structures without the need for permanent implants. Within this context, biodegradable and bioresorbable scaffolds can provide structural and biomechanical stability until the body's own tissue can take over their function. Additive biomanufacturing makes it possible to design the scaffold's architectural characteristics to specifically guide tissue formation and regeneration. Its nano-, micro-, and macro-architectural properties can be tailored to ensure vascularization, oxygenation, nutrient supply, waste exchange, and eventually ossification not only in its periphery but also in its center, which is not in direct contact with osteogenic elements of the surrounding healthy tissue. In this article we provide an overview about our conceptual design and process of the clinical translation of scaffold-based bone tissue engineering applications.
组织工程为再生受损或缺失的骨结构提供了可能性，而无需永久性植入物。在此背景下，可生物降解和生物吸收的支架可提供结构和生物力学稳定性，直至人体自身组织能够接管其功能。增材生物制造能够设计支架的结构特征，以特异性地引导组织形成和再生。其纳米、微米和宏观结构特性可以进行定制，以确保不仅在其周边，而且在其中心（与周围健康组织的成骨元素不直接接触）实现血管化、氧合、营养供应、废物交换，并最终实现骨化。在本文中，我们概述了基于支架的骨组织工程应用的概念设计和临床转化过程。
