State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100043, People's Republic of China.
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People's Republic of China.
Acta Biomater. 2018 Oct 1;79:37-59. doi: 10.1016/j.actbio.2018.08.026. Epub 2018 Aug 28.
Toward the aim of personalized treatment, three-dimensional (3D) printing technology has been widely used in bone tissue engineering owing to its advantage of a fast, precise, and controllable fabrication process. Conventional bioceramic scaffolds are mainly used for bone tissue engineering; however, there has been a significant change in the application of bioceramic scaffolds during the past several years. Therefore, this review focuses on 3D-printed bioceramic scaffolds with different compositions and hierarchical structures (macro, micro, and nano scales), and their effects on the mechanical, degradation, permeability, and biological properties. Further, this review highlights 3D-printed bioceramic scaffolds for applications extending from bone tissue regeneration to bone tumor therapy. This review emphasizes recent developments in functional 3D-printed bioceramic scaffolds with the ability to be used for both tumor therapy and bone tissue regeneration. Considering the challenges in bone tumor therapy, these functional bioceramic scaffolds have a great potential in repairing bone defects induced by surgery and kill the possibly residual tumor cells to achieve bone tumor therapy. Finally, a brief perspective regarding future directions in this field was also provided. The review not only gives a summary of the research developments in bioceramic science but also offers a new therapy strategy by extending multifunctions of traditional biomaterials toward a specific disease.
This review outlines the development tendency of 3D-printed bioceramic scaffolds for applications ranging from bone tissue regeneration to bone tumor therapy. Conventional bioceramic scaffolds are mainly used for bone tissue engineering; however, there has been a significant change in the application of bioceramic scaffolds during the past several years. Therefore, this review focuses on 3D-printed bioceramic scaffolds with different compositions and hierarchical structures (macro, micro, and nano scales), and their effects on the mechanical, degradation, permeability, and biological properties. Further, this review highlights 3D-printed bioceramic scaffolds for applications extending from bone tissue regeneration to bone tumor therapy. This review emphasizes recent developments in the functional 3D-printed bioceramic scaffolds with the ability to be used for both bone tumor therapy and bone tissue regeneration.
为了实现个体化治疗的目标，由于其快速、精确和可控的制造工艺，三维（3D）打印技术已广泛应用于骨组织工程。传统的生物陶瓷支架主要用于骨组织工程；然而，在过去几年中，生物陶瓷支架的应用发生了重大变化。因此，本综述重点介绍了具有不同组成和层次结构（宏观、微观和纳米尺度）的 3D 打印生物陶瓷支架，以及它们对机械性能、降解、渗透性和生物性能的影响。此外，本综述还介绍了 3D 打印生物陶瓷支架在从骨组织再生到骨肿瘤治疗等多个领域的应用。本综述强调了具有肿瘤治疗和骨组织再生双重功能的新型 3D 打印生物陶瓷支架的最新进展。考虑到骨肿瘤治疗的挑战，这些功能生物陶瓷支架在修复手术引起的骨缺损和杀死可能残留的肿瘤细胞以实现骨肿瘤治疗方面具有巨大的潜力。最后，还对该领域的未来发展方向进行了简要展望。本综述不仅总结了生物陶瓷科学的研究进展，还通过将传统生物材料的多种功能扩展到特定疾病，提供了一种新的治疗策略。
