Roux Brianna M, Cheng Ming-Huei, Brey Eric M
Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA; Research Service, Edward Hines Jr. V.A. Hospital, Hines, IL, USA.
J Cell Mol Med. 2015 May;19(5):903-14. doi: 10.1111/jcmm.12569. Epub 2015 Apr 15.
Vascularization remains one of the most important challenges that must be overcome for tissue engineering to be consistently implemented for reconstruction of large volume bone defects. An extensive vascular network is needed for transport of nutrients, waste and progenitor cells required for remodelling and repair. A variety of tissue engineering strategies have been investigated in an attempt to vascularize tissues, including those applying cells, soluble factor delivery strategies, novel design and optimization of bio-active materials, vascular assembly pre-implantation and surgical techniques. However, many of these strategies face substantial barriers that must be overcome prior to their ultimate translation into clinical application. In this review recent progress in engineering vascularized bone will be presented with an emphasis on clinical feasibility.
血管化仍然是组织工程要持续用于大面积骨缺损重建所必须克服的最重要挑战之一。重塑和修复所需的营养物质、废物及祖细胞的运输需要广泛的血管网络。为使组织血管化，人们研究了多种组织工程策略，包括应用细胞、可溶性因子递送策略、生物活性材料的新型设计与优化、血管组装预植入和手术技术。然而，这些策略中的许多都面临着重大障碍，在最终转化为临床应用之前必须加以克服。在本综述中，将介绍工程化血管化骨的最新进展，并重点关注临床可行性。
