de Lestrange-Anginieur Elie, Jiang Xiaoyun, Ren Qiushi
Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, P.R. China.
PLoS One. 2017 Jul 20;12(7):e0181111. doi: 10.1371/journal.pone.0181111. eCollection 2017.
Aberration variations severely degrade retinal imaging in small animal eyes. Previously, the approach of a goggle lens with a matching corneal index was proposed to overcome the on-axis resolution limit of static imaging systems, which allows the use of the full eye pupil. But this technique didn't address the problem of the large power variation, and the ensuing aberration on and off-axis, when dealing with small animal eyes. In this study, we present the concept of a tunable goggle lens, designed to compensate individual ocular aberration for different rodent eye powers. Ray tracing evidences that lens-fitted goggles permit, not only to adjust individual eyes power, but also to surpass conventional adaptive correction technique over large viewing angle, provided a minimum use of two spaced liquids. We believe that the overlooked advantage of the 3D lens function is a seminal finding for further technological advancements in widefield retinal imaging.
像差变化严重降低了小动物眼睛的视网膜成像质量。此前，有人提出使用具有匹配角膜折射率的护目镜透镜来克服静态成像系统的轴上分辨率限制，该方法允许使用整个眼睛的瞳孔。但在处理小动物眼睛时，这种技术并未解决大光焦度变化以及随之而来的轴上和离轴像差问题。在本研究中，我们提出了可调谐护目镜透镜的概念，旨在针对不同啮齿动物眼睛的光焦度补偿个体眼像差。光线追迹表明，配备透镜的护目镜不仅能够调整个体眼睛的光焦度，而且在大视角范围内，通过最少使用两种间隔液体，能够超越传统的自适应校正技术。我们认为，三维透镜功能这一被忽视的优势是宽视场视网膜成像技术进一步发展的开创性发现。
