Bayraktar-Ekincioglu Aygin, Korubük Gamze, Demirkan Kutay
1 Department of Clinical Pharmacy, Faculty of Pharmacy, Hacettepe University, Sihhiye-Ankara, Turkiye.
2 Hacettepe University Hospitals, Oncology Hospital Pharmacy, Sihhiye-Ankara, Turkiye.
J Oncol Pharm Pract. 2018 Dec;24(8):563-573. doi: 10.1177/1078155217720007. Epub 2017 Jul 20.
To identify the practice differences among chemotherapy units and the opinions of pharmacists on safety precautions for handling antineoplastic drugs in hospitals.
The survey was administered to hospital pharmacists in Turkey. The pharmacists who work in chemotherapeutic drug preparation units were asked to participate if they are volunteered. The participating pharmacists were asked questions about the type of chemotherapy units, order and verification process of chemotherapy protocols and potential shortcomings of chemotherapy preparation. The questions were initially assessed in a small sample of pharmacists and subsequently revised and refined. The filled and returned questionnaires were accepted as given consent.
A total of 97 questionnaires were delivered and 40 (41%) were returned by pharmacists. The median age and practicing years in hospitals of the pharmacists were 38.0 and 6.25 years, respectively. Fully automated chemotherapy units were used by 42.5% of respondents, whereas 30% prepare chemotherapeutics manually; furthermore, 87.5% provide chemotherapeutic drug preparations (admixtures) less than 120 per day. With regard to the drug preparation process, more than half of the respondents 'always' use protective equipment without foot covers (32.3%). Almost 90% of respondents 'always' use a coat, mask and biological safety cabinets; however, 20% of respondents 'often' use closed-system drug transfer sets. More than 50% of pharmacists expressed that they have sufficient knowledge on cytotoxics and the risk of exposure, protective precautions, selection and usage of personal protective equipment and correct storage of cytotoxics.
Pharmacists acknowledge sufficient understanding of safe preparation and handling of chemotherapeutics, but reported practices by pharmacists in hospitals are not consistent with published recommendations. Providing theoretical and practical educations for pharmacists and developing standard procedures for preparing chemotherapy may be beneficial in improving the preparation and use of antineoplastics in Turkey.
确定化疗科室之间的实践差异以及药剂师对医院抗肿瘤药物处理安全预防措施的看法。
对土耳其的医院药剂师进行了调查。在化疗药物配制科室工作的药剂师若自愿参与则被邀请参加。向参与的药剂师询问了关于化疗科室类型、化疗方案的医嘱和核查流程以及化疗配制的潜在不足等问题。这些问题首先在一小部分药剂师样本中进行评估，随后进行了修订和完善。填写并返回的问卷被视为已给予同意。
共发放了97份问卷，40名（41%）药剂师返回了问卷。药剂师的中位年龄和在医院的从业年限分别为38.0岁和6.25年。42.5%的受访者使用全自动化疗科室，而30%的科室手动配制化疗药物；此外，87.5%的科室每天提供的化疗药物配制（混合液）少于120份。关于药物配制过程，超过一半的受访者“总是”使用无脚套的防护设备（32.3%）。几乎90%的受访者“总是”穿外套、戴口罩并使用生物安全柜；然而，20%的受访者“经常”使用密闭式药物转移装置。超过50%的药剂师表示他们对细胞毒性药物以及暴露风险、防护措施、个人防护设备的选择和使用以及细胞毒性药物的正确储存有足够的了解。
药剂师承认对化疗药物的安全配制和处理有足够的了解，但医院药剂师报告的实践与已发表的建议不一致。为药剂师提供理论和实践教育以及制定化疗配制的标准程序可能有助于改善土耳其抗肿瘤药物的配制和使用。
