Li Wenchen, Li Shijun, Dai Meifen, Wang Shang, Xiong Yunyun
1 Department of Neurology, Dongyang People's Hospital, Wenzhou Medical University, Dongyang, China.
2 Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Interv Neuroradiol. 2017 Oct;23(5):516-520. doi: 10.1177/1591019917720920. Epub 2017 Jul 20.
Background Whether ASPECTS 5 and ASPECTS 6 were significantly different on clinical outcomes in acute anterior circulation ischemic stroke undergoing endovascular treatment remains unclear. We aimed to retrospectively compare the effectiveness and safety of ASPECTS 5 and ASPECTS 6 in acute anterior circulation large-artery occlusive stroke patients. Methods A total of 41 patients, 14 in the ASPECTS 5 group and 27 in the ASPECTS 6 group, were enrolled between January 2014 and June 2016. Modified Rankin Scale 0-2 was considered as good functional outcome. Symptomatic intracerebral hemorrhage at 72 hours and mortality at 90 days were recorded. Results Good functional outcome at 90 days in the ASPECTS 5 group (0% (0/14)) was significantly lower than that in the ASPECTS 6 group (25.9% (7/27)) ( p = 0.04). Rates of symptomatic intracranial hemorrhage (21.4 (3/14) vs 18.5% (5/27), p = 0.83) and mortality (64.3% (9/14) vs 44.4% (12/27), p = 0.23) within 90 days were not significantly different. There is a trend for a lower rate of successful reperfusion in the ASPECTS 5 group (71.4% (10/14) for ASPECTS 5 vs 92.6% (25/27) for ASPECTS 6, p = 0.07). Conclusions ASPECTS 5 has very little chance to reach good functional outcome in Chinese patients with anterior circulation large-artery occlusive stroke. Future studies with large sample sizes are needed.
对于接受血管内治疗的急性前循环缺血性卒中患者，ASPECTS 5分和ASPECTS 6分在临床结局上是否存在显著差异仍不清楚。我们旨在回顾性比较ASPECTS 5分和ASPECTS 6分在急性前循环大动脉闭塞性卒中患者中的有效性和安全性。方法：2014年1月至2016年6月期间共纳入41例患者，其中ASPECTS 5分组14例，ASPECTS 6分组27例。改良Rankin量表0 - 2分被视为良好的功能结局。记录72小时时的症状性脑出血和90天时的死亡率。结果：ASPECTS 5分组90天时良好功能结局的比例（0%（0/14））显著低于ASPECTS 6分组（25.9%（7/27））（p = 0.04）。90天内症状性颅内出血发生率（21.4%（3/14）对18.5%（5/27），p = 0.83）和死亡率（64.3%（9/14）对44.4%（12/27），p = 0.23）无显著差异。ASPECTS 5分组成功再灌注率有降低趋势（ASPECTS 5为71.4%（10/14），ASPECTS 6为92.6%（25/27），p = 0.07）。结论：在中国前循环大动脉闭塞性卒中患者中，ASPECTS 5分达到良好功能结局的机会很小。需要开展大样本量的未来研究。
