Department of Cardiology, Shandong Provincial Chest Hospital, 46 Lishan Road, Jinan, China.
The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Exp Mol Pathol. 2018 Jun;104(3):222-226. doi: 10.1016/j.yexmp.2018.05.001. Epub 2018 May 14.
Cyclophilin A (CyPA), an abundantly expressed protein belonging to the immunophilin family, is involved in a variety of physiological and pathological activities together with its extracellular receptor, CD147. Many studies have provided compelling evidence supporting critical roles of CyPA in immune and infectious diseases and malignant tumours. Recent studies have revealed that both CyPA and CD147 strongly promote cardiovascular inflammation, myocardial ischaemia-reperfusion injury, and myocardial remodelling processes. Here, we review the potential roles of CyPA and CD147 in cardiac remodelling and their implications for the development of novel pharmacological therapies for heart failure.
亲环素 A（CyPA）是一种丰富表达的蛋白，属于免疫亲和素家族，与细胞外受体 CD147 一起参与多种生理和病理活动。许多研究提供了令人信服的证据，支持 CyPA 在免疫和传染病以及恶性肿瘤中的关键作用。最近的研究表明，CyPA 和 CD147 都强烈促进心血管炎症、心肌缺血再灌注损伤和心肌重构过程。在这里，我们回顾了 CyPA 和 CD147 在心脏重构中的潜在作用及其对心力衰竭新型药物治疗发展的意义。
