Richard J P, Conil J M, Antonini A, Bareille P
Cah Anesthesiol. 1986 Mar-Apr;34(2):125-6.
The authors describe a technique of vecuronium bromide perfusion at constant flow used to obtain curarisation during 50 renal transplantations. The muscular effects of the drug were monitored through an electromyographical recorder, so as to adjust the perfusion rate. The dose of vecuronium bromide was 47.7 +/- 0.74 micrograms X kg-1 X h-1 (mean +/- SEM), this being lower than the dose recommended by D'Hollander (60 micrograms X kg-1 X h-1) for patients with normal renal function. Furthermore, no recurarisation was observed. Therefore, vecuronium can be considered as a satisfactory muscle relaxant in patients with renal failure, but neuromuscular monitoring appears to be a most important safety factor.
作者描述了一种在50例肾移植手术中使用的以恒定流速灌注维库溴铵来实现肌松的技术。通过肌电图记录仪监测药物的肌肉效应，以便调整灌注速率。维库溴铵的剂量为47.7±0.74微克·千克⁻¹·小时⁻¹（平均值±标准误），这低于D'Hollander为肾功能正常患者推荐的剂量（60微克·千克⁻¹·小时⁻¹）。此外，未观察到再箭毒化现象。因此，维库溴铵可被视为肾衰竭患者令人满意的肌肉松弛剂，但神经肌肉监测似乎是一个非常重要的安全因素。
