Fragen R J, Shanks C A
Anesth Analg. 1984 Jan;63(1):51-4.
Vecuronium bromide, 0.045 mg X kg-1, was compared with pancuronium, 0.07 mg X kg-1, when used to provide muscle relaxation for tracheal intubation and abdominal relaxation for outpatient gynecologic laparoscopy. Both drugs provided adequate intubating conditions within 5 min and satisfactory abdominal relaxation. Because spontaneous recovery from vecuronium was more rapid, either with inhalational or nitrous oxide-narcotic techniques, pharmacological reversal with edrophonium and atropine was either not necessary or more easily accomplished after vecuronium, as shown by the train-of-four. All patients receiving pancuronium required reversal of the blockade, and in a few patients reversal was difficult. Tests of muscle power and coordination performed 30 and 60 min postoperatively showed no difference between the drugs. There were no postoperative complications related to muscle relaxants and all patients met our discharge criteria the day of surgery. Given the conditions observed at the end of the procedure, we would choose vecuronium for muscular relaxation in laparoscopic surgery.
在用于为气管插管提供肌肉松弛以及为门诊妇科腹腔镜检查提供腹部松弛时，将0.045毫克/千克的溴化维库溴铵与0.07毫克/千克的泮库溴铵进行了比较。两种药物均在5分钟内提供了足够的插管条件以及令人满意的腹部松弛效果。由于无论是采用吸入技术还是氧化亚氮-麻醉技术，维库溴铵的自主恢复都更快，如四个成串刺激所示，使用依酚氯铵和阿托品进行药理学拮抗在使用维库溴铵后要么没有必要，要么更容易完成。所有接受泮库溴铵的患者都需要进行阻滞拮抗，并且在少数患者中拮抗很困难。术后30分钟和60分钟进行的肌肉力量和协调性测试显示，两种药物之间没有差异。没有与肌肉松弛剂相关的术后并发症，所有患者在手术当天均符合我们的出院标准。鉴于手术结束时观察到的情况，我们会选择维库溴铵用于腹腔镜手术中的肌肉松弛。
