Roaiah M F, Elkhayat Y I, Rashed L A, GamalEl Din S F, El Guindi A M, Abd El Salam M A
Andrology, STDs Cairo University, Cairo, Egypt.
Biochemistry, Cairo University, Cairo, Egypt.
Andrologia. 2018 Mar;50(2). doi: 10.1111/and.12855. Epub 2017 Jul 21.
We investigated the prevalence of 5HT2C receptor gene polymorphisms in Egyptian patients with lifelong premature ejaculation. A total of 350 participants were enrolled in a prospective study. Two hundred and forty-five cases with lifelong premature ejaculation joined this study, in addition to 105 controls. We instructed the partners of the cases to measure the IELT of the first intercourse only using a stopwatch for 1 month. Genotyping was carried out at the end of the study. The results showed that the majority of the patients and controls were Cys/Cys. A highly significant statistical association was found between the studied gene polymorphisms and IELT among cases (p-values = .009). The study emphasised the potential role of 5HT2C receptor gene polymorphisms in patients with lifelong premature ejaculation.
我们调查了埃及终生早泄患者中5HT2C受体基因多态性的患病率。共有350名参与者纳入一项前瞻性研究。除105名对照者外，245例终生早泄患者加入本研究。我们指导病例的伴侣仅使用秒表测量首次性交的阴道内射精潜伏期，为期1个月。研究结束时进行基因分型。结果显示，大多数患者和对照者为Cys/Cys。在病例中，研究的基因多态性与阴道内射精潜伏期之间发现了高度显著的统计学关联（p值 = 0.009）。该研究强调了5HT2C受体基因多态性在终生早泄患者中的潜在作用。
