Mendels J, Schless A P
J Clin Psychiatry. 1986 Jul;47(7):357-61.
Ninety-eight outpatients with major depressive disorder were treated with alprazolam, imipramine, or placebo in a 6-week, double-blind study. Average doses were 3.67 mg of alprazolam and 167 mg of imipramine, given at bedtime. Fifty percent of patients taking alprazolam, 38.2% taking imipramine, and 17.7% receiving placebo improved their HAM-D scores by more than 50%. Eight patients on imipramine, 6 on alprazolam, and 1 on placebo dropped out because of side effects. The most common side effects for imipramine were tachycardia, constipation, light-headedness, and sedation; common side effects of alprazolam were light-headedness, sedation, and unsteadiness.
在一项为期6周的双盲研究中，98名重度抑郁症门诊患者接受了阿普唑仑、丙咪嗪或安慰剂治疗。平均剂量为睡前服用3.67毫克阿普唑仑和167毫克丙咪嗪。服用阿普唑仑的患者中有50%、服用丙咪嗪的患者中有38.2%、接受安慰剂的患者中有17.7%的汉密尔顿抑郁量表（HAM-D）得分改善超过50%。8名服用丙咪嗪的患者、6名服用阿普唑仑的患者和1名服用安慰剂的患者因副作用退出。丙咪嗪最常见的副作用是心动过速、便秘、头晕和镇静；阿普唑仑的常见副作用是头晕、镇静和不稳。
