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立陶宛成年男性中与酒精相关死亡率相关的个体和地区层面特征:基于与人口普查关联数据的多层次分析。

Individual- and area-level characteristics associated with alcohol-related mortality among adult Lithuanian males: A multilevel analysis based on census-linked data.

作者信息

Grigoriev Pavel, Jasilionis Domantas, Stumbrys Daumantas, Stankūnienė Vladislava, Shkolnikov Vladimir M

机构信息

Max Planck Institute for Demographic Research (Rostock, Germany).

Demographic Research Centre, Vytautas Magnus University (Kaunas, Lithuania).

出版信息

PLoS One. 2017 Jul 21;12(7):e0181622. doi: 10.1371/journal.pone.0181622. eCollection 2017.

Abstract

BACKGROUND

Although excessive alcohol-related mortality in the post-Soviet countries remains the major public health threat, determinants of this phenomenon are still poorly understood.

AIMS

We assess simultaneously individual- and area-level factors associated with an elevated risk of alcohol-related mortality among Lithuanian males aged 30-64.

METHODS

Our analysis is based on a census-linked dataset containing information on individual- and area-level characteristics and death events which occurred between March 1st, 2011 and December 31st, 2013. We limit the analysis to a few causes of death which are directly linked to excessive alcohol consumption: accidental poisonings by alcohol (X45) and liver cirrhosis (K70 and K74). Multilevel Poisson regression models with random intercepts are applied to estimate mortality rate ratios (MRR).

RESULTS

The selected individual-level characteristics are important predictors of alcohol-related mortality, whereas area-level variables show much less pronounced or insignificant effects. Compared to married men, never married (MRR = 1.9, CI:1.6-2.2), divorced (MRR = 2.6, CI:2.3-2.9), and widowed (MRR = 2.4, CI: 1.8-3.1) men are disadvantaged groups. Men who have the lowest level of educational attainment have the highest mortality risk (MRR = 1.7 CI:1.4-2.1). Being unemployed is associated with a five-fold risk of alcohol-related death (MRR = 5.1, CI: 4.4-5.9), even after adjusting for all other individual variables. Lithuanian males have an advantage over Russian (MRR = 1.3, CI:1.1-1.6) and Polish (MRR = 1.8, CI: 1.5-2.2) males. After adjusting for all individual characteristics, only two out of seven area-level variables-i.e., the share of ethnic minorities in the population and the election turnout-have statistically significant direct associations. These variables contribute to a higher risk of alcohol-related mortality at the individual level.

CONCLUSIONS

The huge and increasing socio-economic disparities in alcohol-related mortality indicate that recently implemented anti-alcohol measures in Lithuania should be reinforced by specific measures targeting the most disadvantaged population groups and geographical areas.

摘要

背景

尽管后苏联国家与酒精相关的过高死亡率仍是主要的公共卫生威胁,但对这一现象的决定因素仍知之甚少。

目的

我们同时评估立陶宛30至64岁男性中与酒精相关死亡率升高风险相关的个体层面和地区层面因素。

方法

我们的分析基于一个与人口普查相关的数据集,该数据集包含个体层面和地区层面特征以及2011年3月1日至2013年12月31日期间发生的死亡事件的信息。我们将分析限制在与过量饮酒直接相关的几种死因上:酒精意外中毒(X45)和肝硬化(K70和K74)。应用具有随机截距的多水平泊松回归模型来估计死亡率比(MRR)。

结果

所选的个体层面特征是与酒精相关死亡率的重要预测因素,而地区层面变量的影响则不太明显或不显著。与已婚男性相比,从未结婚的男性(MRR = 1.9,CI:1.6 - 2.2)、离婚男性(MRR = 2.6,CI:2.3 - 2.9)和丧偶男性(MRR = 2.4,CI:1.8 - 3.1)是弱势群体。教育程度最低的男性死亡率风险最高(MRR = 1.7,CI:1.4 - 2.1)。即使在对所有其他个体变量进行调整后,失业与酒精相关死亡风险增加五倍相关(MRR = 5.1,CI:4.4 - 5.9)。立陶宛男性比俄罗斯男性(MRR = 1.3,CI:1.1 - 1.6)和波兰男性(MRR = 1.8,CI:1.5 - 2.2)具有优势。在对所有个体特征进行调整后,七个地区层面变量中只有两个——即少数民族在人口中的比例和选举投票率——具有统计学上显著的直接关联。这些变量在个体层面导致与酒精相关死亡率的更高风险。

结论

酒精相关死亡率方面巨大且不断增加的社会经济差距表明,立陶宛最近实施的反酒精措施应通过针对最弱势群体和地理区域的具体措施加以强化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f70e/5521820/ec4e24baeac7/pone.0181622.g001.jpg

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