Furuse Yuki, Fallah Mosoka, Oshitani Hitoshi, Kituyi Ling, Mahmoud Nuha, Musa Emmanuel, Gasasira Alex, Nyenswah Tolbert, Dahn Bernice, Bawo Luke
Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.
Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan.
PLoS Negl Trop Dis. 2017 Jul 21;11(7):e0005804. doi: 10.1371/journal.pntd.0005804. eCollection 2017 Jul.
An outbreak of Ebola virus disease (EVD) in Liberia began in March 2014 and ended in January 2016. Epidemiological information on the EVD cases was collected and managed nationally; however, collection and management of the data were challenging at the time because surveillance and reporting systems malfunctioned during the outbreak. EVD diagnostic laboratories, however, were able to register basic demographic and clinical information of patients more systematically. Here we present data on 16,370 laboratory samples that were tested between April 4, 2014 and March 29, 2015. A total of 10,536 traceable individuals were identified, of whom 3,897 were confirmed cases (positive for Ebola virus RNA). There were significant differences in sex, age, and place of residence between confirmed and suspected cases that tested negative for Ebola virus RNA. Age (young children and the elderly) and place of residence (rural areas) were the risk factors for death due to the disease. The case fatality rate of confirmed cases decreased from 80% to 63% during the study period. These findings may help support future investigations and lead to a fuller understanding of the outbreak in Liberia.
利比里亚的埃博拉病毒病（EVD）疫情始于2014年3月，于2016年1月结束。关于埃博拉病毒病病例的流行病学信息在全国范围内收集和管理；然而，当时数据的收集和管理具有挑战性，因为疫情期间监测和报告系统出现故障。不过，埃博拉病毒病诊断实验室能够更系统地登记患者的基本人口统计学和临床信息。在此，我们展示了2014年4月4日至2015年3月29日期间检测的16370份实验室样本的数据。总共识别出10536名可追踪个体，其中3897例为确诊病例（埃博拉病毒RNA呈阳性）。埃博拉病毒RNA检测呈阴性的确诊病例与疑似病例在性别、年龄和居住地点方面存在显著差异。年龄（幼儿和老年人）和居住地点（农村地区）是该疾病导致死亡的风险因素。在研究期间，确诊病例的病死率从80%降至63%。这些发现可能有助于支持未来的调查，并使人们对利比里亚的疫情有更全面的了解。
