Division of Molecular Technologies, Research Institute of Translational Medicine, N.I.Pirogov Russian National Research Medical University, Ostrovitianova str. 1, Moscow, 117997, Russia.
Institute of Numerical Mathematics, RAS, Moscow, Russia.
Reprod Biol Endocrinol. 2017 Jul 20;15(1):54. doi: 10.1186/s12958-017-0268-z.
The cause of contamination and dissemination of leiomyoma tissue particles and cells in the peritoneal cavity during myomectomy is a challenging issue for both clinicians and researchers. Therefore, the article by Huang et al. recently published in your journal is the subject of this letter.
We comment on the role of laparoscopic condition in xenograft implantation and also highlighted the shortcomings of this study. The surgical technique of intramural fibroid enucleation, cell spillage during morcellation and postsurgical hormonal impact on the development of parasitic myomas become evident, while the contribution of CO2 insufflation, the fibroid's nature, mutations and pseudocapsule impacts on angiogenesis are not clear. In addition, an exploration of the exact origin of implanted fragments harvested from the fibroid tissue and their nature might play a significant role in the implantation and the angiogenesis induction ability of xenografts.
Taking into account the current literature in the scope of this study, we suggest that the factors involved in development of parasitic myomas can be classified as confirmed and doubtful contributions.
子宫肌瘤剔除术中，肌瘤组织颗粒和细胞在腹腔内的污染和播散是临床医生和研究人员面临的挑战。因此，最近发表在贵刊的 Huang 等人的文章是这封信讨论的主题。
我们评论了腹腔镜条件在异种移植物植入中的作用，并强调了这项研究的局限性。子宫肌瘤核除术的手术技术、在分碎过程中细胞溢出以及术后激素对寄生性子宫肌瘤发展的影响是显而易见的，而 CO2 充气、肌瘤的性质、突变和假包膜对血管生成的影响则不清楚。此外，对从肌瘤组织中采集的植入碎片的确切来源及其性质进行探索，可能对异种移植物的植入和血管生成诱导能力起着重要作用。
考虑到本研究范围内的现有文献，我们认为，寄生性子宫肌瘤发展的相关因素可分为明确和可疑的作用。
