Bak-Pedersen K, Larsen P K
Acta Otolaryngol Suppl. 1979;360:138-40. doi: 10.3109/00016487809123499.
111 patients with cystic fibrosis (CF), aged 7 months to 29 years, were examined to detect inflammatory middle ear diseases. 35% had a history of one or more attacks of acute otitis media, an incidence at the same level as in non-CF patients. None had chronic suppurative otitis. Only 4 out of the 88 patients able to cooperate in audiometry had a hearing impairment. In 2, the hearing loss was perceptive, in 3 very mild, and in the fourth case, moderately severe. The middle ear pressure was measured in 108 patients, in 86 of whom it proved normal. In 15 patients the middle ear pressure was lower than--100 mmH2O, indicating tubal occlusion, and in 7 patients the impedance minimum was lacking, indicating an accumulation of mucus. These 7 patients (6%) had secretory otitis media. Nasal polyps were or had been present in 32%. There was no correlation between nasal polyps and tubal occlusion or secretory otitis. The incidence of inflammatory middle ear diseases in CF patients was in the same range as in non-CF patients, a finding at variance with some previous investigations showing middle ear pathology in 25--48%.
对111例年龄在7个月至29岁之间的囊性纤维化（CF）患者进行了检查，以检测中耳炎性疾病。35%的患者有过一次或多次急性中耳炎发作史，其发病率与非CF患者相同。无一例患有慢性化脓性中耳炎。在88例能够配合进行听力测定的患者中，只有4例有听力障碍。其中2例听力损失为感音性，3例非常轻微，第4例为中度严重。对108例患者测量了中耳压力，其中86例结果正常。15例患者的中耳压力低于 -100 mmH₂O，表明咽鼓管堵塞，7例患者缺乏声阻抗最小值，表明有黏液积聚。这7例患者（6%）患有分泌性中耳炎。32%的患者有或曾有鼻息肉。鼻息肉与咽鼓管堵塞或分泌性中耳炎之间无相关性。CF患者中耳炎性疾病的发病率与非CF患者处于同一范围，这一发现与之前一些显示中耳病变率为25% - 48%的研究结果不同。
