Nano-food Research Group, Instrumental and Food Analysis Laboratory, Industrial Biotechnology Division, School of BioSciences and Technology, VIT University, Vellore, Tamil Nadu, India; Department of Agricultural, Food and Nutritional Science, Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, Canada.
Nano-food Research Group, Instrumental and Food Analysis Laboratory, Industrial Biotechnology Division, School of BioSciences and Technology, VIT University, Vellore, Tamil Nadu, India.
Ultrason Sonochem. 2017 Nov;39:623-635. doi: 10.1016/j.ultsonch.2017.05.021. Epub 2017 May 17.
Recently, nanoemulsions have been employed for different applications including food and drug industries for efficient nutrient delivery system. In this study, vitamin D (a lipophilic molecule) was encapsulated in fish oil for higher oral bioavailability. The oil-in-water nanoemulsion was formulated by ultrasonication technique with a droplet size range of 300-450nm and a shelf life of more than 90days. The influence of oil, water and surfactant concentration was investigated by phase diagram. The formulated nanoemulsion had encapsulation efficiency in the range of 95.7-98.2%. Further, nanoemulsion passed through simulated gastro-intestinal tract revealed an increased bioavailability than non-encapsulated vitamin. Thus, the formulation can be used as a drug delivery vehicle for various lipophilic compounds. Till date, no one have fabricated an efficient nano-vehicle for the delivery of vitamin D as well as analyzed the efficient delivery system in simulated GI-tract, this is first of its kind study in this regard. This can be scaled up further after analyzing the safety aspects.
最近，纳米乳已被应用于不同领域，包括食品和制药行业，以作为高效的营养传递系统。在本研究中，维生素 D（亲脂性分子）被包裹在鱼油中以提高其口服生物利用度。采用超声技术制备油包水型纳米乳，粒径范围为 300-450nm，保质期超过 90 天。通过相图研究了油、水和表面活性剂浓度的影响。所制备的纳米乳的包封效率在 95.7-98.2%范围内。此外，纳米乳通过模拟胃肠道的实验显示出比非包封维生素更高的生物利用度。因此，该配方可用作各种脂溶性化合物的药物传递载体。迄今为止，还没有人制造出用于输送维生素 D 的高效纳米载体，也没有人在模拟胃肠道中分析有效的输送系统，这是在这方面的首例研究。在分析了安全性方面之后，可以进一步扩大规模。
