Sharifan Payam, Hassanzadeh Elahe, Mohammadi-Bajgiran Maryam, Dabbagh Vahid Reza, Aminifar Elham, Ghazizadeh Hamideh, Saffar-Soflaei Sara, Darroudi Susan, Tanbakouchi Davoud, Fazl-Mashhadi Mohammad Reza, Ebrahimi-Dabagh Ali, Mohammadi Mohammad Amin, Hemmatpur Anahid, Ferns Gordon A, Esmaily Habibollah, Sadeghi Ramin, Ghayour-Mobarhan Majid
International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Arch Bone Jt Surg. 2022 Jul;10(7):601-610. doi: 10.22038/ABJS.2021.57547.2850.
Bone disease-related fractures constitute a heavy burden on the healthcare systems and economy. Vitamin D is an important regulator of bone health and its deficiency is a global problem. This study aimed to evaluate the effect of the 1,500 IU nano-encapsulated vitamin D used for fortifying low-fat dairy products (milk and yogurt) on bone health parameters.
This parallel totally blinded, randomized controlled trial was part of the Ultraviolet Intake by Nutritional Approach study and conducted on 306 individuals with abdominal obesity. Individuals were randomly assigned to four groups, including fortified low-fat milk (1,500 IU nano-encapsulated vitamin D3 per 200 g/d), non-fortified low-fat milk, fortified low-fat yogurt (1,500 IU nano-encapsulated vitamin D3 per 150 g/d), and non-fortified low-fat yogurt, for 10 weeks between January and March 2019. Bone mineral density (BMD) and trabecular bone score (TBS) were measured at the baseline and end of the trial. Trabecular bone score and BMD were defined as primary and secondary outcomes.
There were no significant differences in TBS and BMD between the intervention and control groups at the end of the trial ().
This trial demonstrated no significant effect of nano-encapsulated vitamin D fortified milk and yogurt on BMD and TBS. There remains a need for longer-term trials regarding bone health outcomes to establish optimal doses of fortification.
与骨病相关的骨折给医疗系统和经济带来沉重负担。维生素D是骨骼健康的重要调节因子，其缺乏是一个全球性问题。本研究旨在评估用于强化低脂乳制品（牛奶和酸奶）的1500国际单位纳米包裹维生素D对骨骼健康参数的影响。
这项平行、完全盲法、随机对照试验是营养途径紫外线摄入研究的一部分，对306名腹部肥胖个体进行。个体被随机分为四组，包括强化低脂牛奶（每200克/天含1500国际单位纳米包裹维生素D3）、未强化低脂牛奶、强化低脂酸奶（每150克/天含1500国际单位纳米包裹维生素D3）和未强化低脂酸奶，于2019年1月至3月期间进行为期10周的试验。在试验基线和结束时测量骨密度（BMD）和小梁骨评分（TBS）。小梁骨评分和BMD被定义为主要和次要结局。
试验结束时，干预组和对照组之间的TBS和BMD没有显著差异（）。
该试验表明，纳米包裹维生素D强化的牛奶和酸奶对BMD和TBS没有显著影响。仍需要进行关于骨骼健康结局的长期试验，以确定最佳强化剂量。
