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激光疗法联合富血小板血浆对大鼠肌肉损伤再生的组织学分析。

Histological analysis of the association of low level laser therapy and platelet-rich plasma in regeneration of muscle injury in rats.

机构信息

Universidade Estadual de Campinas (UNICAMP), Programa de Pós-graduação em Ciências da Cirurgia, Campinas, SP, Brazil.

Universidade Estadual Paulista (UNESP),Departamento de Fisioterapia, Presidente Prudente, SP, Brazil.

出版信息

Braz J Phys Ther. 2017 Nov-Dec;21(6):425-433. doi: 10.1016/j.bjpt.2017.06.007. Epub 2017 Jul 4.

DOI:10.1016/j.bjpt.2017.06.007
PMID:28733091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5693427/
Abstract

OBJECTIVE

Muscle injuries are common, and their treatment requires costs and time off. Platelet rich plasma and low level laser therapy have been shown to be affordable and easy to use. The aim of this study was to evaluate the associated effects of low level laser therapy and platelet rich plasma on the treatment of the soleus muscle injured by strain in rats.

METHODS

Thirty-five rats were randomly allocated into five groups: Control (C), Injury Control (IC), injury PRP (IP), injury LLLT (ILT) and injury LLLT and PRP (ILTP). The strain injury was induced in the soleus muscle and the IP group received application of platelet rich plasma immediately after the lesion, while the ILT group received low level laser therapy. After seven days, all animals were euthanized and the soleus muscle removed for further histological analysis.

RESULTS

The association of both treatments (ILTP) resulted in better histological aspects than the low level laser therapy and platelet rich plasma alone, when compared with the injury group (IC). The collagen analysis exhibited a significant increase in the ILT group (2.99 SD=1.13) compared to the C (1.88 SD=0.41, p=0.012) and IP (2.04 SD=0.44, p=0.018).

CONCLUSION

The association of low level laser therapy with platelet rich plasma produced better results on muscle injury compared to the isolated use of these therapies. Furthermore, none of the treatments could modulate the collagen deposition in relation to injury group.

摘要

目的

肌肉损伤很常见，其治疗需要花费时间和金钱。富血小板血浆和低水平激光疗法已被证明是经济实惠且易于使用的。本研究的目的是评估低水平激光疗法和富血小板血浆联合应用于大鼠比目鱼肌拉伤的治疗效果。

方法

35 只大鼠随机分为 5 组：对照组（C）、损伤对照组（IC）、损伤富血小板血浆组（IP）、损伤低水平激光组（ILT）和损伤低水平激光联合富血小板血浆组（ILTP）。比目鱼肌拉伤造模后，IP 组立即给予富血小板血浆，ILT 组给予低水平激光治疗。7 天后，所有动物处死，取出比目鱼肌进行组织学分析。

结果

与损伤组（IC）相比，两种治疗方法（ILTP）的联合应用在组织学方面的效果优于单独使用低水平激光疗法和富血小板血浆。与 C 组（1.88 SD=0.41，p=0.012）和 IP 组（2.04 SD=0.44，p=0.018）相比，ILT 组的胶原分析显示出显著增加（2.99 SD=1.13）。

结论

与单独使用这些疗法相比，低水平激光疗法联合富血小板血浆在肌肉损伤方面产生了更好的效果。此外，与损伤组相比，这些治疗方法均不能调节胶原沉积。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35b8/5693427/436d5b4fa5af/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35b8/5693427/927eec705757/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35b8/5693427/c115b4dc897a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35b8/5693427/436d5b4fa5af/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35b8/5693427/927eec705757/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35b8/5693427/c115b4dc897a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35b8/5693427/436d5b4fa5af/gr4.jpg

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