Cardiff China Medical Research CollaborativeCardiff University School of Medicine, Cardiff, UK.
Cardiff China Medical Research CollaborativeCardiff University School of Medicine, Cardiff, UK
Endocr Relat Cancer. 2017 Oct;24(10):R349-R366. doi: 10.1530/ERC-17-0139. Epub 2017 Jul 21.
Bone morphogenetic proteins (BMPs) belong to the TGF-β super family, and are essential for the regulation of foetal development, tissue differentiation and homeostasis and a multitude of cellular functions. Naturally, this has led to the exploration of aberrance in this highly regulated system as a key factor in tumourigenesis. Originally identified for their role in osteogenesis and bone turnover, attention has been turned to the potential role of BMPs in tumour metastases to, and progression within, the bone niche. This is particularly pertinent to breast cancer, which commonly metastasises to bone, and in which studies have revealed aberrations of both BMP expression and signalling, which correlate clinically with breast cancer progression. Ultimately a BMP profile could provide new prognostic disease markers. As the evidence suggests a role for BMPs in regulating breast tumour cellular function, in particular interactions with tumour stroma and the bone metastatic microenvironment, there may be novel therapeutic potential in targeting BMP signalling in breast cancer. This review provides an update on the current knowledge of BMP abnormalities and their implication in the development and progression of breast cancer, particularly in the disease-specific bone metastasis.
骨形态发生蛋白（BMPs）属于 TGF-β超家族，对于调节胎儿发育、组织分化和稳态以及多种细胞功能至关重要。自然而然，这导致人们探索这个高度调控系统中的失常作为肿瘤发生的关键因素。BMPs 最初因其在成骨和骨转换中的作用而被识别，人们开始关注 BMP 在肿瘤转移到骨和在骨龛内进展中的潜在作用。这对于乳腺癌尤为重要，乳腺癌通常会转移到骨，研究表明 BMP 的表达和信号转导都发生了异常，这与乳腺癌的进展具有临床相关性。最终，BMP 谱可能提供新的预后疾病标志物。由于有证据表明 BMP 在调节乳腺癌细胞功能方面发挥作用，特别是与肿瘤基质和骨转移微环境的相互作用，因此在乳腺癌中靶向 BMP 信号可能具有新的治疗潜力。本综述提供了关于 BMP 异常及其在乳腺癌发生和发展中，特别是在特定于疾病的骨转移中的作用的最新知识更新。
