新生儿空肠弯曲菌脑膜炎的医院内暴发。

Nosocomial outbreak of Campylobacter jejuni meningitis in newborn infants.

作者信息

Goossens H, Henocque G, Kremp L, Rocque J, Boury R, Alanio G, Vlaes L, Hemelhof W, Van den Borre C, Macart M

出版信息

Lancet. 1986 Jul 19;2(8499):146-9. doi: 10.1016/s0140-6736(86)91956-2.

DOI:10.1016/s0140-6736(86)91956-2

Abstract

In a nosocomial outbreak of Campylobacter jejuni infection 11 newborn infants (7 female, 4 male) had meningitis. The outbreak was caused by a single strain of C jejuni, as demonstrated by biotyping (biotype I), serotyping (LAU 7/PEN 18 on heat-stable antigens, a new serotype on heat-labile antigens), and the identical susceptibility pattern and outer-membrane-protein profile on sodium dodecyl sulphate/polyacrylamide gel electrophoresis. Specific antibodies against the outbreak strain (enzyme-linked immunosorbent assay and Western blot) developed in all the babies. They were treated with gentamicin and ampicillin. All but one baby, who had a moderately dilated left lateral ventricle after the meningitis, recovered well. The source of infection could not be clearly determined. Thus, C jejuni can cause serious nosocomial infection; it should be considered as a possible agent of meningitis of unknown origin, particularly in newborn infants and other compromised hosts.

摘要

在一次空肠弯曲菌感染的医院内暴发中，11名新生儿（7名女性，4名男性）患了脑膜炎。此次暴发由单一菌株的空肠弯曲菌引起，这通过生物分型（生物型I）、血清分型（热稳定抗原上为LAU 7/PEN 18，热不稳定抗原上为一种新血清型）以及十二烷基硫酸钠/聚丙烯酰胺凝胶电泳上相同的药敏模式和外膜蛋白图谱得以证明。所有婴儿体内都产生了针对暴发菌株的特异性抗体（酶联免疫吸附测定和蛋白质印迹法）。他们接受了庆大霉素和氨苄西林治疗。除一名婴儿在脑膜炎后左侧脑室中度扩张外，其他所有婴儿恢复良好。感染源无法明确确定。因此，空肠弯曲菌可导致严重的医院感染；它应被视为不明原因脑膜炎的可能病原体，尤其是在新生儿和其他免疫功能低下的宿主中。