Goossens H, Henocque G, Kremp L, Rocque J, Boury R, Alanio G, Vlaes L, Hemelhof W, Van den Borre C, Macart M
Lancet. 1986 Jul 19;2(8499):146-9. doi: 10.1016/s0140-6736(86)91956-2.
In a nosocomial outbreak of Campylobacter jejuni infection 11 newborn infants (7 female, 4 male) had meningitis. The outbreak was caused by a single strain of C jejuni, as demonstrated by biotyping (biotype I), serotyping (LAU 7/PEN 18 on heat-stable antigens, a new serotype on heat-labile antigens), and the identical susceptibility pattern and outer-membrane-protein profile on sodium dodecyl sulphate/polyacrylamide gel electrophoresis. Specific antibodies against the outbreak strain (enzyme-linked immunosorbent assay and Western blot) developed in all the babies. They were treated with gentamicin and ampicillin. All but one baby, who had a moderately dilated left lateral ventricle after the meningitis, recovered well. The source of infection could not be clearly determined. Thus, C jejuni can cause serious nosocomial infection; it should be considered as a possible agent of meningitis of unknown origin, particularly in newborn infants and other compromised hosts.
在一次空肠弯曲菌感染的医院内暴发中，11名新生儿（7名女性，4名男性）患了脑膜炎。此次暴发由单一菌株的空肠弯曲菌引起，这通过生物分型（生物型I）、血清分型（热稳定抗原上为LAU 7/PEN 18，热不稳定抗原上为一种新血清型）以及十二烷基硫酸钠/聚丙烯酰胺凝胶电泳上相同的药敏模式和外膜蛋白图谱得以证明。所有婴儿体内都产生了针对暴发菌株的特异性抗体（酶联免疫吸附测定和蛋白质印迹法）。他们接受了庆大霉素和氨苄西林治疗。除一名婴儿在脑膜炎后左侧脑室中度扩张外，其他所有婴儿恢复良好。感染源无法明确确定。因此，空肠弯曲菌可导致严重的医院感染；它应被视为不明原因脑膜炎的可能病原体，尤其是在新生儿和其他免疫功能低下的宿主中。
