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根瘤菌RT1群体感应分子在细菌运动性和生物膜形成中的作用。

Roles of quorum sensing molecules from Rhizobium etli RT1 in bacterial motility and biofilm formation.

作者信息

Dixit Swarnita, Dubey Ramesh Chand, Maheshwari Dinesh Kumar, Seth Prahlad Kishore, Bajpai Vivek K

机构信息

Department of Botany and Microbiology, Gurukul Kangri University, Haridwar, Uttrakhand, India.

Biotech Park, Sector G, Jankipuram, Kursi Road, Lucknow, UP, India.

出版信息

Braz J Microbiol. 2017 Oct-Dec;48(4):815-821. doi: 10.1016/j.bjm.2016.08.005. Epub 2017 Jul 8.

DOI:10.1016/j.bjm.2016.08.005
PMID:28735852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5628318/
Abstract

Strain RT1 was isolated from root nodules of Lens culinaris (a lentil) and characterized as Rhizobium etli (a Gram-negative soil-borne bacterium) by 16S rDNA sequencing and phylogenetic analysis. The signaling molecules produced by R. etli (RT1) were detected and identified by high-performance liquid chromatography coupled with mass spectrometry. The most abundant and biologically active N-acyl homoserine lactone molecules (3-oxo-C-HSL and 3-OH-C-HSL) were detected in the ethyl acetate extract of RT1. The biological role of 3-oxo-C-HSL was evaluated in RT1. Bacterial motility and biofilm formation were affected or modified on increasing concentrations of 3-oxo-C-HSL. Results confirmed the existence of cell communication in RT1 mediated by 3-oxo-C-HSL, and positive correlations were found among quorum sensing, motility and biofilm formation in RT1.

摘要

菌株RT1从兵豆（一种小扁豆）的根瘤中分离得到，并通过16S rDNA测序和系统发育分析鉴定为费氏中华根瘤菌（一种革兰氏阴性土传细菌）。通过高效液相色谱-质谱联用技术对费氏中华根瘤菌（RT1）产生的信号分子进行了检测和鉴定。在RT1的乙酸乙酯提取物中检测到了最丰富且具有生物活性的N-酰基高丝氨酸内酯分子（3-氧代-C-HSL和3-羟基-C-HSL）。对RT1中3-氧代-C-HSL的生物学作用进行了评估。随着3-氧代-C-HSL浓度的增加，细菌的运动性和生物膜形成受到影响或发生改变。结果证实了RT1中存在由3-氧代-C-HSL介导的细胞通讯，并且在RT1的群体感应、运动性和生物膜形成之间发现了正相关关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1974/5628318/5545c09ddc7b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1974/5628318/ea6ae87c3331/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1974/5628318/39d908c18ac5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1974/5628318/65a05fb28d62/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1974/5628318/d16e5a6f31fa/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1974/5628318/5545c09ddc7b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1974/5628318/ea6ae87c3331/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1974/5628318/39d908c18ac5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1974/5628318/65a05fb28d62/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1974/5628318/d16e5a6f31fa/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1974/5628318/5545c09ddc7b/gr5.jpg

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