Wang Xiaoli, Yu Haobing, Zhang Yixin, Lu Xiaoling, Wang Bin, Liu Xiaoyu
Marine Biopharmaceutical Institute, Second Military Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.
Marine Science and Technology College, Zhejiang Ocean University, 1 South Haida Road, Zhoushan, 316022, P. R. China.
Chem Biodivers. 2018 Jan;15(1). doi: 10.1002/cbdv.201700276. Epub 2017 Dec 21.
Marine organisms represent an abundant sources of bioactive natural products with unique chemical structure. Pimarane diterpenes are a structurally diverse family of natural products with various biological activities and pharmacological properties. A prolific source of new marine-derived pimarane diterpenes have attracted considerable interest because of their unique structural diversity and varied biological activities, including antimicrobial, antitumor, and antiproliferative activities. This review provides a comprehensive overview of the structures, names, bioactivities, and references of 80 marine-derived pimarane-type natural products for the first time.
海洋生物是具有独特化学结构的生物活性天然产物的丰富来源。海松烷二萜是一类结构多样的天然产物，具有多种生物活性和药理特性。新的海洋来源海松烷二萜的丰富来源因其独特的结构多样性和多种生物活性，包括抗菌、抗肿瘤和抗增殖活性，而引起了相当大的兴趣。本综述首次全面概述了80种海洋来源海松烷型天然产物的结构、名称、生物活性和参考文献。
