Degertekin H, Ertan A, Akdamar K, Groot K, Godiwala T, Mather F J, Arimura A
Dig Dis Sci. 1986 Aug;31(8):833-9. doi: 10.1007/BF01296052.
This study investigates release of somatostatin-like immunoreactivity (SLI) into the gastric lumen of five healthy human subjects in response to pharmacological stimuli (pentagastrin and secretin) and physiological stimuli (sham feeding and intrajejunal perfusion of elemental diet). Basal and poststimulation gastric juice aspirates were collected at 15-min intervals, extracted with acetone, and SLI determined by radioimmunoassay, with these results: A considerable amount of SLI was secreted during the basal period. Pentagastrin stimulated SLI release quickly and was associated with increased acid secretion. Both secretin and sham feeding increased SLI only slightly. During intrajejunal perfusion of the elemental diet, SLI increased significantly, was associated with decreased acid secretion, and rapidly returned to basal level when elemental diet was replaced by saline. Basal levels of gastric luminal SLI thus showed distinct changes in response to each stimulus. Although the physiological action of luminal SLI remains to be studied, its levels may reflect gastric D-cell activities.
本研究调查了5名健康人类受试者胃腔内生长抑素样免疫反应性（SLI）对药理学刺激（五肽胃泌素和促胰液素）和生理刺激（假饲和空肠内灌注要素饮食）的释放情况。每隔15分钟收集基础期和刺激后的胃液抽吸物，用丙酮提取，通过放射免疫测定法测定SLI，结果如下：基础期分泌了相当数量的SLI。五肽胃泌素迅速刺激SLI释放，并与胃酸分泌增加有关。促胰液素和假饲仅轻微增加SLI。在空肠内灌注要素饮食期间，SLI显著增加，与胃酸分泌减少有关，当要素饮食被盐水替代时，SLI迅速恢复到基础水平。因此，胃腔内SLI的基础水平对每种刺激均表现出明显变化。尽管腔内SLI的生理作用仍有待研究，但其水平可能反映胃D细胞的活性。
