Sarfati P D, Green G M, Brazeau P, Morisset J
Can J Physiol Pharmacol. 1986 May;64(5):539-44. doi: 10.1139/y86-089.
These studies were performed to assess the effects of various exocrine pancreatic stimuli on somatostatin-like immunoreactivity (SLI) secretion in pure rat pancreatic juice. Ingestion of a meal and subcutaneous injections of caerulein (CA), secretin (SE), and their combination (CA + SE) were compared. Basal fasting SLI output over 5 1/2 h averaged 13.7 ng/30 min; the response to feeding resulted in decreased SLI outputs from 9.7 to 1.7 ng/30 min, a reduction of 81%. SLI secretion following CA, SE, and CA + SE was similar to that obtained following feeding but the reductions of 29, 32, and 39% were less marked and of shorter duration. A return to basal SLI levels was observed only 2 1/2 h following CA administration. Increases in pancreatic volume and protein outputs following CA, SE, and CA + SE were comparable to the feeding response although less pronounced. These data indicate that SLI secretion in pure pancreatic juice can be modulated by two peptides and feeding and that its release is reduced when compared with increases in pancreatic volume and protein secretion. The observation that the peptide's response in terms of SLI output as well as protein and volume were in the same range, although less sustained than the response to a meal, indicates that all stimuli used induced a physiological response of the pancreas.
进行这些研究是为了评估各种外分泌性胰腺刺激对纯大鼠胰液中生长抑素样免疫反应性（SLI）分泌的影响。比较了进食以及皮下注射蛙皮素（CA）、促胰液素（SE）及其组合（CA + SE）的效果。5个半小时的基础空腹SLI输出平均为13.7 ng/30分钟；进食后的反应导致SLI输出从9.7 ng/30分钟降至1.7 ng/30分钟，降低了81%。CA、SE和CA + SE后的SLI分泌与进食后的情况相似，但分别降低29%、32%和39%的幅度较小且持续时间较短。仅在注射CA后2个半小时观察到SLI水平恢复到基础水平。CA、SE和CA + SE后胰腺体积和蛋白质输出的增加与进食反应相当，尽管不太明显。这些数据表明，纯胰液中的SLI分泌可受两种肽和进食的调节，与胰腺体积和蛋白质分泌增加相比，其释放减少。尽管该肽在SLI输出以及蛋白质和体积方面的反应不如对进食的反应持久，但在同一范围内，这一观察结果表明所有使用的刺激均诱导了胰腺的生理反应。
