Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, 71515, Egypt.
Department of Surgery, Faculty of Medicine, Assiut University, Assiut, Egypt.
Sci Rep. 2017 Jul 24;7(1):6340. doi: 10.1038/s41598-017-06955-w.
Drug incompatibilities are considered as one of the most critical problems in intensive care units. In the current study, the ability of nanomaterials to prevent drug incompatibilities in clinical settings has been investigated. As a proof-of-concept, the ability of niosomes to prevent physical and chemical incompatibilities that occur upon mixing acyclovir and vancomycin during management of acute meningitis has been explored. Nanosized spherical particles loaded separately with either vancomycin or acyclovir, with high entrapment efficiency (ca. 46-56%), could be prepared, and sustained release of their entrapped cargoes have been demonstrated over time. We have shown that precipitation, degradation and loss of biological activity of drugs occurred upon mixing solutions of the free drugs. On the contrary, drugs loaded separately inside niosomal structures exhibited high stability, exceptional physical and chemical compatibilities for up to 48 h with complete preservation of the antimicrobial activity of vancomycin. This study opens a venue for a new spectrum of applications of nanomaterials in preventing clinically significant drug incompatibilities, aiming at the reduction of adverse reactions, cost and hospitalization period, and improvement of patient compliance and therapeutic outcomes.
药物不相容性被认为是重症监护病房中最严重的问题之一。在本研究中，研究了纳米材料在临床环境中预防药物不相容性的能力。作为概念验证，研究了脂质体纳米囊泡预防阿昔洛韦和万古霉素混合用于治疗急性脑膜炎时发生的物理和化学不相容性的能力。可以制备分别负载万古霉素或阿昔洛韦的纳米尺寸的球形颗粒，包封效率高（约 46-56%），并随着时间的推移证明其包封货物的持续释放。我们已经表明，当混合游离药物的溶液时，药物会发生沉淀、降解和丧失生物活性。相反，分别负载在脂质体结构内的药物表现出高度的稳定性，在长达 48 小时内具有出色的物理和化学相容性，万古霉素的抗菌活性完全保留。这项研究为纳米材料在预防临床上有意义的药物不相容性方面的新应用开辟了途径，旨在减少不良反应、成本和住院时间，提高患者的依从性和治疗效果。
