Department of Integrative Biosciences & Biotechnology, Pohang University of Science and Technology(POSTECH), 77 Cheongam-Ro, Pohang, Gyeongbuk, 37673, Republic of Korea.
R&D Center, NovMetaPharma Co., Ltd., 394 Jigok-Ro, Pohang, Gyeongbuk, 37668, Republic of Korea.
Sci Rep. 2017 Jul 24;7(1):6237. doi: 10.1038/s41598-017-05303-2.
Robust mitochondrial respiration provides energy to support physical performance and physiological well-being, whereas mitochondrial malfunction is associated with various pathologies and reduced longevity. In the current study, we tested whether myricetin, a natural flavonol with diverse biological activities, may impact mitochondrial function and longevity. The mice were orally administered myricetin (50 mg/kg/day) for 3 weeks. Myricetin significantly potentiated aerobic capacity in mice, as evidenced by their increased running time and distance. The elevated mitochondrial function was associated with induction of genes for oxidative phosphorylation and mitochondrial biogenesis in metabolically active tissues. Importantly, myricetin treatment led to decreased PGC-1α acetylation through SIRT1 activation. Furthermore, myricetin significantly improved the healthspan and lifespan of wild-type, but not Sir-2.1-deficient, C. elegans. These results demonstrate that myricetin enhances mitochondrial activity, possibly by activating PGC-1α and SIRT1, to improve physical endurance, strongly suggesting myricetin as a mitochondria-activating agent.
强大的线粒体呼吸为身体机能和生理健康提供能量支持，而线粒体功能障碍与各种疾病和寿命缩短有关。在本研究中，我们测试了杨梅素（一种具有多种生物活性的天然类黄酮）是否可能影响线粒体功能和寿命。将小鼠经口给予杨梅素（50mg/kg/天）3 周。杨梅素显著增强了小鼠的有氧能力，表现在它们的跑步时间和距离增加。线粒体功能的提高与氧化磷酸化和线粒体生物发生基因在代谢活跃组织中的诱导有关。重要的是，杨梅素通过 SIRT1 激活来降低 PGC-1α 的乙酰化。此外，杨梅素显著改善了野生型秀丽隐杆线虫的健康寿命和寿命，但对 Sir-2.1 缺失型秀丽隐杆线虫没有影响。这些结果表明，杨梅素通过激活 PGC-1α 和 SIRT1 来增强线粒体活性，从而提高身体耐力，强烈表明杨梅素是一种激活线粒体的物质。
